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Evaluation of Synergistic Interaction Between Cytokines and Peptide Epitope Vaccines in Protection Against HER-2 Expressing Lung Metastases

  • Naveen Dakappagari
  • Robin Parihar
  • John Pyles
  • William E. Carson
  • Pravin T. P. Kaumaya
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

HER-2, a member of the epidermal growth factor receptor family is overexpressed in 25–30% of breast, ovarian and colon cancers. HER-2 overexpression is associated with poor prognosis and resistance to chemo- and hormonal therapies. We recently reported that chimeric peptide vaccines incorporating a B-cell epitope of HER-2 and “promiscuous” T-helper cell epitope from measles virus are capable of eliciting high levels of native receptor reactive antibodies. In addition, these chimeric peptide vaccines were capable of preventing the spontaneous formation of mammary tumors in HER-2/neu transgenic mice [2]. Ongoing phase lb clinical trials in cancer patients indicate that the chimeric peptide vaccines can induce antibodies capable of killing human cancer cells.

Keywords

Measle Virus Peptide Vaccine Tumor Cell Lysis Epidermal Growth Factor Receptor Family Chimeric Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Adris, S., Chuluyan, E., Bravo, A., Berenstein, M., Klein, S., Jasnis, M., Carbone, C., Chemajovsky, Y., Podhajcer, O.L. Cancer Res. 60, 6696–6703 (2000).PubMedGoogle Scholar
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    Dakappagari, N.K., Douglas, D.B., Triozzi, P.L., Stevens, V.C., Kaumaya, P.T. Cancer Res. 60, 3782–3789 (2000).PubMedGoogle Scholar
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    Gan, Y.H., Zhang, Y., Khoo, H.E., Esuvaranathan, K. Eur. J. Cancer 35, 1123–1129 (1999).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Naveen Dakappagari
    • 3
  • Robin Parihar
    • 4
  • John Pyles
    • 3
  • William E. Carson
    • 4
    • 5
    • 6
  • Pravin T. P. Kaumaya
    • 1
    • 2
    • 3
    • 6
  1. 1.Department of Obstetrics and GynecologyThe Ohio State UniversityColumbusUSA
  2. 2.Department of Molecular and Cellular BiochemistryThe Ohio State UniversityColumbusUSA
  3. 3.Department of MicrobiologyThe Ohio State UniversityColumbusUSA
  4. 4.Department of Molecular Virology, Immunology, GeneticsThe Ohio State UniversityColumbusUSA
  5. 5.Department of SurgeryThe Ohio State UniversityColumbusUSA
  6. 6.Arthur G. James Comprehensive Cancer CenterThe Ohio State UniversityColumbusUSA

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