Translocation of Various Arginine-Rich Peptides and the Potential of These Peptides as Carriers for Intracellular Protein Delivery
Recently, methods have been developed for the delivery of exogenous proteins into living cells with the help of membrane-permeable carrier peptides such as HIV-1 Tat-(48–60) and Antennapedia-(43–58). By hybridizing these carrier peptides genetically or chemically, efficient intracellular delivery of various oligopeptides and proteins was achieved [1,2]. These methods would become powerful tools not only for therapeutic purposes, but also for the understanding of the mechanisms behind fundamental cellular events, such as signal transduction and gene transcription.
KeywordsAmide Cysteine Arginine Resi Cytosol
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