Translocation of Various Arginine-Rich Peptides and the Potential of These Peptides as Carriers for Intracellular Protein Delivery

  • Shiroh Futaki
  • Tomoki Suzuki
  • Wakana Ohashi
  • Takeshi Yagami
  • Seigo Tanaka
  • Kunihiro Ueda
  • Yukio Sugiura
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

Recently, methods have been developed for the delivery of exogenous proteins into living cells with the help of membrane-permeable carrier peptides such as HIV-1 Tat-(48–60) and Antennapedia-(43–58). By hybridizing these carrier peptides genetically or chemically, efficient intracellular delivery of various oligopeptides and proteins was achieved [1,2]. These methods would become powerful tools not only for therapeutic purposes, but also for the understanding of the mechanisms behind fundamental cellular events, such as signal transduction and gene transcription.

Keywords

Amide Cysteine Arginine Resi Cytosol 

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References

  1. 1.
    Schwarze, S.R., Dowdy, S.F. Trends Pharmacol Sci. 21, 45–48 (2000).PubMedCrossRefGoogle Scholar
  2. 2.
    Derossi, D., Chassaing, G., Prochiantz, A. Trends Cell Biol. 8, 84–87 (1998).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Shiroh Futaki
    • 1
  • Tomoki Suzuki
    • 1
  • Wakana Ohashi
    • 1
  • Takeshi Yagami
    • 1
  • Seigo Tanaka
    • 1
  • Kunihiro Ueda
    • 1
  • Yukio Sugiura
    • 1
  1. 1.Institute for Chemical ResearchKyoto UniversityUji, KyotoJapan

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