Abstract
Cyclization of peptides is an important method for identifying active molecules, stabilizing and elucidating receptor-bound conformations, and ultimately developing lead compounds. As such, we have been interested in the rapid synthesis of discrete cyclic peptide libraries using a novel “safety catch” linker 1 [1]. This linker allows BOC solid-phase peptide assembly and on completion is unmasked using deprotection conditions commonly employed within peptide chemistries (HF or strong acid). The resulting linking group permits cyclization of the linear peptide, with concomitant cleavage upon neutralization of the N-terminal amine.
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Bourne, G.T., McGeary, R.P., Golding, S.W., Meutermans, W.D.F., Smythe, M.L. In Fields G.B., Tarn, J.P., and Barany, G. (Eds) Peptides, Biology and Chemistry (Proceedings of the 16th American Peptide Symposium), Kluwer Dordrecht, 2000, p. 98–99.
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© 2001 Springer Science+Business Media Dordrecht
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Golding, S.W., Bourne, G.T., Meutermans, W.D.F., Jones, A., Smythe, M.L. (2001). The Use of a Novel Safety Catch Linker for BOC-Based Assembly of Cyclic Peptide Libraries. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_38
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DOI: https://doi.org/10.1007/978-94-010-0464-0_38
Publisher Name: Springer, Dordrecht
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