HPLC Analysis, Modeling, and Biological Studies of Antiproliferative Heterocyclic Carboxamides

  • János Seprõdi
  • Ferenc Hollósy
  • Dániel Erõs
  • László Õrfi
  • István Teplán
  • György Kéri
  • Miklós Idei
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

Reversed phase HPLC and MEKC [1] provide excellent possibilities to measure the hydrophobic properties of compounds, characterizing them directly from the chromatographic retention time. The aim in this respect is to estimate the hydrophobic character of the molecules on the basis of their retention factors (k′) determined in various separation processes [1]. The expected biological activity of the compounds can be reliably predicted on the basis of the measured hydrophobicity data [2]. Another possibility is the use of highly sophisticated computer programs to calculate hydrophobicity on the basis of the structural moieties building up the molecule being investigated.

Keywords

HPLC Electrophoresis Furan Carboxamides Tamas 

References

  1. 1.
    Idei, M., Kiss, É., Kéri, Gy. Electrophoresis 17, 762–765 (1996).PubMedCrossRefGoogle Scholar
  2. 2.
    Idei, M., Gyõrffy, E., Kiss, É., Õrfi, L., Seprõdi, J., Tamás, B., Hollósy, F., Mészáros, Gy., Kéri, Gy. Electrophoresis 20, 1561–1567 (1999).PubMedCrossRefGoogle Scholar
  3. 3.
    Hollósy F., Mészáros Gy., Bökönyi Gy, Idei M., Seprõdi A., Szende B., Kéri, Gy. Anticancer Res. 20, 4563–4570 (2000).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • János Seprõdi
    • 1
  • Ferenc Hollósy
    • 1
  • Dániel Erõs
    • 2
  • László Õrfi
    • 2
  • István Teplán
    • 1
  • György Kéri
    • 1
  • Miklós Idei
    • 1
  1. 1.Department of Medical Chemistry & Peptide Biochemistry Research GroupSemmelweis UniversityBudapestHungary
  2. 2.Institute of Pharmaceutical ChemistrySemmelweis UniversityBudapestHungary

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