In vivo Proteolytic Hemoglobin Products as Tissue Growth Promoters
It is well known that growth factors are responsible for maintenance of cell proliferation in vitro and in vivo. At the same time, the ability to stimulate cell proliferation in vitro was demonstrated for endogenous fragments of functional proteins, defined earlier as components of tissue-specific peptide pools . Neokyotorphin, the a-globin (137–141) fragment, has been shown earlier to stimulate proliferation of L929 transformed murine fibroblasts and brown preadipocytes independently on the presence of fetal bovine serum (FBS) [2–4]. We have studied the in vitro proliferative effects of the peptides corresponding to the a-globin (133–141) segment, and on the basis of the data obtained suggested their function in the organism.