Abstract
Cecropins [1] and melittins [2] are a group of potent antimicrobial peptides. The cecropin melittin analogs are highly antimicrobial [3], had antitumor activity [4] and cecropins are potent fungicides [5]. To understand the role of substitution of hydrophobic amino acids with hydrophilic amino acids and Aib, different substituted analogs were separately synthesized and their antimicrobial activity studied.
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References
Hultmark, D., Steiner, H., Rasmunson, T., Boman, H.G. Eur. J. Biochem. 106, 7–16 (1980).
Habermann, E., Jentsch, J. Hoppe-Seyler’s Z. Physiol Chem. 348, 37–50 (1967).
Andreu, D., Ubach, J., Boman, A., Wahlin, B., Wade, D., Merrifield, R.B. FEBS Lett. 296, 190–194 (1992).
Shin, S.Y., Kang, J.H., Hahn, K.S. J. Peptide Res.53, 82–90 (1999).
Andra, J., Berninghausen, O., Leippe, M. Med. Microbiol. Immunol. 189, 169–173 (2001).
Juvvadi, P., Vunnam, S., Merrifield, E.L., Boman, H.G., Merrifield, R.B. J. Peptide Sci. 2, 223–232 (1996).
Merrifield, R.B. J. Am. Chem. Soc. 85, 2149–2154 (1963).
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© 2001 Springer Science+Business Media Dordrecht
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Juvvadi, P., Vunnam, S., Yoo, B., Merrifield, B. (2001). Synthesis and Study of the Antimicrobial Action of Cecropin A-Melittin Hybrids with Aib Substitution. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_357
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DOI: https://doi.org/10.1007/978-94-010-0464-0_357
Publisher Name: Springer, Dordrecht
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