Synthesis and Study of the Antimicrobial Action of Cecropin A-Melittin Hybrids with Aib Substitution

  • Padmaja Juvvadi
  • Satyanarayana Vunnam
  • Barney Yoo
  • Bruce Merrifield
Part of the American Peptide Symposia book series (APSY, volume 7)


Cecropins [1] and melittins [2] are a group of potent antimicrobial peptides. The cecropin melittin analogs are highly antimicrobial [3], had antitumor activity [4] and cecropins are potent fungicides [5]. To understand the role of substitution of hydrophobic amino acids with hydrophilic amino acids and Aib, different substituted analogs were separately synthesized and their antimicrobial activity studied.


Antimicrobial Activity Bacillus Subtilis Peptide Analog High Antimicrobial Activity Hybrid Analog 
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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Padmaja Juvvadi
    • 1
  • Satyanarayana Vunnam
    • 1
  • Barney Yoo
    • 1
  • Bruce Merrifield
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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