Synthesis and Study of the Antimicrobial Action of Cecropin A-Melittin Hybrids with Aib Substitution
Cecropins  and melittins  are a group of potent antimicrobial peptides. The cecropin melittin analogs are highly antimicrobial , had antitumor activity  and cecropins are potent fungicides . To understand the role of substitution of hydrophobic amino acids with hydrophilic amino acids and Aib, different substituted analogs were separately synthesized and their antimicrobial activity studied.
KeywordsHPLC Agarose Amide Bacillus Pseudomonas
- 6.Juvvadi, P., Vunnam, S., Merrifield, E.L., Boman, H.G., Merrifield, R.B. J. Peptide Sci. 2, 223–232 (1996).Google Scholar