Abstract
The Wang resin is one of the most commonly used solid polymers in SPPS. An Fmoc strategy for the lengthening of the peptide chain is compatible with the final acid cleavage of the peptide-resin bond. To increase tactic possibilities, it would be interesting to be able to use the Boc group on this resin type. Classical acid conditions (TFA 30 to 90% in DCM) for Boc removal cleave the peptide from the Wang resin simultaneously. Therefore, we investigated new conditions for deprotecting the Boc group which would preserve the peptide-resin bond.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Kaiser Sr., E., Tarn, J.P., Kubiak, T.M., Merrifield, R.B. Tetrahedron Lett. 29, 303–306 (1988).
Zhang, A.J., Russell, D.H., Zhu J., Burgess, K. Tetrahedron Lett. 39, 7439–7442 (1998).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Cavelier, F., Lejeune, V., Martinez, J. (2001). Towards a Selective Boc Deprotection on Acid Cleavable Resin. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_35
Download citation
DOI: https://doi.org/10.1007/978-94-010-0464-0_35
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3905-5
Online ISBN: 978-94-010-0464-0
eBook Packages: Springer Book Archive