Abstract
Angiotensin II (AII) is an octapeptide, produced in the blood as a result of two different enzymatic hydrolyses, which occur in the renal hypertensor system. Among many others pharmacological properties, angiotensin II exerts its effects in the smooth and visceral muscles, peripheral and central nervous system and in the induction of aldosterone releasing from the cortex adrenal gland. As a potent pressor agent it plays an important role in the blood pressure regulation. Many efforts have been done in order to establish the AII receptor-bound conformation. As the molecule is very flexible in solution, one of the most successful strategies is the use of conformationally constrained AII analogues by disulfide [1,2] or lactam bridges [3,4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Zhang, W.J., Nikiforovich, G.V., Pérodin, J., Richard, D.E., Escher, E., Marshal, G.R. J. Med. Chem. 39, 2738–2744 (1996).
Lindman, S., Lindeberg, G., Gogoll, A., Nyberg, F., Karlen, A., Hallberg, A. Bioorg. Med. Chem. 9, 763–772 (2001).
Matsoukas, J.M., Hondrelis, J., Agelis, G., Barlos, K., Gatos, D., Ganter, R., Moore, D., Moore, G.J. J. Med. Chem. 37, 2958–2969 (1994).
Matsoukas, J.M., Polevaya, L., Ancans, J., Mavromoustakos, T., Kolocouris, A., Roumelioti, P., Vlahakos, D.V., Yamdagni, R., Wu, Q., Moore, G.J. Bioorg. Med. Chem. 8, 1–10 (2000).
Miranda, A., Koerber, S.C., Gulyas, J., Lahrichi, S.L., Craig, A.G., Corrigan, A., Hagler, A., Rivier, C., Vale, W., Rivier, J. J. Med. Chem. 37, 1450–1459 (1994).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Oliveira, V.X., Schreier, S., Casallanovo, F., Paiva, T.B., Paiva, A.C.M., Miranda, A. (2001). Conformational Studies of Angiotensin II Cyclic Analogues. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_337
Download citation
DOI: https://doi.org/10.1007/978-94-010-0464-0_337
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3905-5
Online ISBN: 978-94-010-0464-0
eBook Packages: Springer Book Archive