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Conformational Studies of Angiotensin II Cyclic Analogues

  • Vani X. OliveiraJr.
  • Shirley Schreier
  • Fabio Casallanovo
  • Therezinha B. Paiva
  • Antonio C. M. Paiva
  • Antonio Miranda
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

Angiotensin II (AII) is an octapeptide, produced in the blood as a result of two different enzymatic hydrolyses, which occur in the renal hypertensor system. Among many others pharmacological properties, angiotensin II exerts its effects in the smooth and visceral muscles, peripheral and central nervous system and in the induction of aldosterone releasing from the cortex adrenal gland. As a potent pressor agent it plays an important role in the blood pressure regulation. Many efforts have been done in order to establish the AII receptor-bound conformation. As the molecule is very flexible in solution, one of the most successful strategies is the use of conformationally constrained AII analogues by disulfide [1,2] or lactam bridges [3,4].

Keywords

Cortex Adrenal Gland Blood Pressure Regulation Conformational Study Cyclic Analogue Main Functional Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Vani X. OliveiraJr.
    • 1
  • Shirley Schreier
    • 2
  • Fabio Casallanovo
    • 2
  • Therezinha B. Paiva
    • 1
  • Antonio C. M. Paiva
    • 1
  • Antonio Miranda
    • 1
  1. 1.Department of BiophysicsUNIFESPBrazil
  2. 2.Department of BiochemistryIQ-USPSão PauloBrazil

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