Conformational Studies of Angiotensin II Cyclic Analogues
Angiotensin II (AII) is an octapeptide, produced in the blood as a result of two different enzymatic hydrolyses, which occur in the renal hypertensor system. Among many others pharmacological properties, angiotensin II exerts its effects in the smooth and visceral muscles, peripheral and central nervous system and in the induction of aldosterone releasing from the cortex adrenal gland. As a potent pressor agent it plays an important role in the blood pressure regulation. Many efforts have been done in order to establish the AII receptor-bound conformation. As the molecule is very flexible in solution, one of the most successful strategies is the use of conformationally constrained AII analogues by disulfide [1,2] or lactam bridges [3,4].
KeywordsHydrolysis Carboxyl Angiotensin Disulfide Aldosterone