Stereoselective Synthesis of Tyrψ[CH2O]Phe and Tyrψ[CH2O]Ile, Methylene-oxy Analogs of Oxytocin and [8-Arginine]Vasopressin

  • Jan Mařík
  • Jan Hlaváček
  • Miloš Buděšínský
  • Jiřina Slaninová
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

Methylene-oxy replacement ψ[CH2O] of the peptide bond provides flexible, lipophilic surrogates with enhanced metabolical stability. Moreover the geometry of the methylene-oxy surrogates resembles the geometry of the peptide bond in extended conformation [1,2].

References

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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Jan Mařík
    • 1
  • Jan Hlaváček
    • 1
  • Miloš Buděšínský
    • 1
  • Jiřina Slaninová
    • 1
  1. 1.Institute of Organic Chemistry and BiochemistryAcademy of Sciences of the Czech RepublicPragueCzech Republic

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