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Stepwise Peptide-Peptoid Transformation via SPOT Synthesis

  • Ulrich Reineke
  • Berit Hoffmann
  • Thomas Ast
  • Thomas Polakowski
  • Jens Schneider-Mergener
  • Rudolf Volkmer-Engert
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

Bioactive peptides are promising lead structures for the development of novel drugs. However, peptides have many drawbacks for their direct use as therapeutics such as degradation by proteases and low bioavailability. These limitations can be overcome by their transformation into peptidomimetics.

Keywords

Bioactive Peptide Natural Amino Acid Small Organic Compound Substitutional Analysis Remain Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Ulrich Reineke
    • 1
  • Berit Hoffmann
    • 2
  • Thomas Ast
    • 1
    • 2
  • Thomas Polakowski
    • 1
  • Jens Schneider-Mergener
    • 1
    • 2
  • Rudolf Volkmer-Engert
    • 2
  1. 1.Jerini AGBerlinGermany
  2. 2.Institut für Medizinische Immunologie, CharitéHumboldt-Universität zu BerlinBerlinGermany

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