New Approach for Preparation of C-Glycoamino Acid Building Blocks

  • Istvan Jablonkai
Part of the American Peptide Symposia book series (APSY, volume 7)


Oxygen-linked glycopeptides are vital constituents of biological membranes and their carbohydrate moieties play key role in molecular recognition processes [1]. However, O-glycosidic bonds in these molecules are sensitive to both chemical and enzymatic deglycosylation. Preparation of the hydrolytically more stable C-glycosylated analogs has attracted much attention recently. The objectives of this study were to prepare β-and β-amino acids ß-linked to the carbohydrate moiety as building blocks in combinatorial approaches to generate glycopeptide mimetics by solid phase peptide synthesis methods.


Boron Trifluoride Carbohydrate Moiety Sodium Cyanide Racemic Amino Acid Enzymatic Deglycosylation 
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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Istvan Jablonkai
    • 1
  1. 1.Institute of Chemistry, Chemical Research CenterHungarian Academy of SciencesBudapestHungary

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