New Approach for Preparation of C-Glycoamino Acid Building Blocks

  • Istvan Jablonkai
Part of the American Peptide Symposia book series (APSY, volume 7)

Abstract

Oxygen-linked glycopeptides are vital constituents of biological membranes and their carbohydrate moieties play key role in molecular recognition processes [1]. However, O-glycosidic bonds in these molecules are sensitive to both chemical and enzymatic deglycosylation. Preparation of the hydrolytically more stable C-glycosylated analogs has attracted much attention recently. The objectives of this study were to prepare β-and β-amino acids ß-linked to the carbohydrate moiety as building blocks in combinatorial approaches to generate glycopeptide mimetics by solid phase peptide synthesis methods.

Keywords

Sugar Boron Aldehyde MeOH Cyanide 

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Copyright information

© Springer Science+Business Media Dordrecht 2001

Authors and Affiliations

  • Istvan Jablonkai
    • 1
  1. 1.Institute of Chemistry, Chemical Research CenterHungarian Academy of SciencesBudapestHungary

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