Abstract
Previously described syntheses of lactam-constrained dipeptide amino acids involve lengthy and expensive procedures to obtain an aldehyde intermediate 4 [1]. We report a general route from D-glutamic acid to lactam-dipeptide units. The target lactam-constrained amino acid has a six-membered ring back-bone and isopropyl and isobutyl side-chains (Figure 1). The overall synthesis is shown in Figure 2.
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© 2001 Springer Science+Business Media Dordrecht
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Oguz, U., Gauthier, T.J., McLaughlin, M.L. (2001). Facile Synthesis of a Constrained Dipeptide Unit (DPU) for Use as a β-Sheet Promoter. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_17
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DOI: https://doi.org/10.1007/978-94-010-0464-0_17
Publisher Name: Springer, Dordrecht
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