Abstract
Solid-phase parallel synthesis is used worldwide to generate libraries of small organic compounds in order to accelerate the drug discovery process [1]. The focus of this field of research, which initially involved the synthesis of peptides and oligonucleotides, is now on the synthesis of small organic molecules on the solid-phase. Heterocycles, such as benzodiazepines, hydantoins, pyrrolidines, and bicyclic guanidines, have received special attention in combinatorial synthesis due to their biological interesting properties [2]. This strategy has permitted the synthesis of large numbers of heterocycles in a short time frame, enabling their use in high-throughput screening. Compounds containing the 1,2,4-triazine moiety are in use as pharmaceuticals, pesticides, herbicides etc. [3]. As part of our ongoing efforts directed toward the solid phase synthesis of small molecule and heterocyclic compounds and the generation of their combinatorial libraries [4], we report here an efficient method for the synthesis of l,2,4-triazinan-3-ones from resin-bound acylated amino acid amides.
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© 2001 Springer Science+Business Media Dordrecht
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Yu, Y., Ostresh, J.M., Houghten, R.A. (2001). Solid Phase Synthesis of 1,2,4-Triazinan-3-ones. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_117
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DOI: https://doi.org/10.1007/978-94-010-0464-0_117
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