Myth: Dietary protein restriction slows progression of renal insufficiency
According to Mitch et al. (1) low-protein diets alleviate uremic symptoms and some complications of chronic renal failure (CRF). Low-protein diets are viewed as nutritionally sound in CRF patients because they activate compensatory mechanisms that conserve body muscle mass. In one of several prospective, randomized studies of the efficacy of protein restric-tion in slowing the rate of progression of renal impairment, Ihle et al. (2) found that ESRD developed in nine of 33 patients on unmodified diets as compared with only two of 31 patients on a protein-restricted diet.
KeywordsPhosphorus Urea Creatinine Proteinuria Hyperparathyroidism
Unable to display preview. Download preview PDF.
- 3.Fraga AR, Baron R, Haedo AS, Martin RS, Arrizurieta EE. Protein restriction and progression of chronic renal failure. Medicina (B Aires). 1992;52:41–47.Google Scholar
- 6.Bakris GL, Whelton P, Weir M, Mimran A, Keane W, Schiffrin E. The future of clinical trials in chronic renal disease: outcome of an NIH/FDA physician specialist conference. Evaluation of clinical trial endpoints in chronic renal disease study group. J Clin Pharm. 2000;40:815–825.CrossRefGoogle Scholar
- 8.Levey AS, Greene T, Beck GJ, Caggiula AW, Kusek JW, Hunsicker LG, Klahr S, and The Modification of Diet in Renal Disease (MDRD) Study Group. Dietary restriction and the progression of chronic renal disease: what have all of the results of the MDRD study shown? J Am Soc Nephrol. 1999;10:2426–2439.PubMedGoogle Scholar