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Protein Translocation Across the Outer Membrane of Mitochondria

Structure and function of the TOM complex of Neurospora crassa

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Book cover Structure and Dynamics of Confined Polymers

Part of the book series: NATO Science Series ((ASHT,volume 87))

Abstract

Transport of nuclear encoded proteins into mitochondria is mediated by distinct translocation machinery in the outer and inner mitochondrial membranes. At the outer membrane, import is facilitated by a multi-subunit complex called TOM. The role of individual TOM components in recognition and translocation of preproteins will be discussed. Specific characteristics of the protein-conducting channel and the three-dimensional structure of the TOM complex isolated from Neurospora crassa and determined by electron microscopy are described.

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Authors and Affiliations

  1. Institute of Physiological Chemistry, University of Munich, Goethestraße 33, München, D-80336, Germany

    Stephan Nussberger & Walter Neupert

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  1. Stephan Nussberger
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  2. Walter Neupert
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  1. Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, USA

    John J. Kasianowicz

  2. Department of Biophysics, Pécs University Medical School, Pécs, Hungary

    Miklós S. Z. Kellermayer

  3. Biophysics Laboratory, Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    David W. Deamer

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Nussberger, S., Neupert, W. (2002). Protein Translocation Across the Outer Membrane of Mitochondria. In: Kasianowicz, J.J., Kellermayer, M.S.Z., Deamer, D.W. (eds) Structure and Dynamics of Confined Polymers. NATO Science Series, vol 87. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0401-5_4

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