Abstract
Auxin-regulated gene expression is mediated by two families of transcription factors. The ARF proteins bind to a conserved DNA sequence called the AuxRE and activate, transcription. The Aux/IAA proteins repress ARF function, presumably by forming dimers with ARF proteins. Recent genetic studies in Arabidopsis indicate that auxin regulates this system by promoting the ubiquitin-mediated degradation of the Aux/IAA proteins, thus permitting ARF function. Mutations in components of SCFTIR1, a ubiquitin protein ligase (E3) result in stabilization of Aux/IAA proteins and decreased auxin response. Further, recent biochemical experiments indicate that the Aux/IAA proteins bind SCFTIR1 in an auxin-dependent manner.
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Dharmasiri, S., Estelle, M. (2002). The role of regulated protein degradation in auxin response. In: Perrot-Rechenmann, C., Hagen, G. (eds) Auxin Molecular Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0377-3_11
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DOI: https://doi.org/10.1007/978-94-010-0377-3_11
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