Abstract
Prevalent opinion on the mode of action of protein hydrolysates considered the hydrolysates as rich sources of nutrients (e.g., Heidemann et al., 2000). Our previous work dealing with chromatography fractions of plant protein hydrolysates pointed to an alternative explanation. We suggested that protein hydrolysates might also serve as a source of peptides endowed with specific activities (Franëk and Katinger, 2000).
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References
Franěk, F., Hohenwarter, G., and Katinger, H. (2000) Plant Protein Hydrolysates: Preparation of Defined Peptide Fractions Promoting Growth and Production in Animal Cells Cultures. Biotechnol. Prog. 16, 688–692.
Franěk, F., and Šráamková, K. (1996) Cell Suicide in Starving Hybridoma Culture: Survival-Signal Effect of Some Amino Acids. Cytotechnology 21, 81–89.
Heidemann, R., Zhang, C, Qi, H., Rule, J. L., Rozales, C, Park, S., Chuppa, S., Ray, M., Michaels, J., Konstantinov, K., and Naveh, D. (2000) The Use of Peptones as Medium Additives for the Production of a Recombinant Therapeutic Protein in High-Density Perfusion Cultures of Mammallian Cells. Cytotechnology 32, 157–167.
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© 2001 Springer Science+Business Media Dordrecht
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Franěk, F., Katinger, H. (2001). Specific Effects of Synthetic Oligopeptides in Animal Cell Culture. In: Lindner-Olsson, E., Chatzissavidou, N., Lüllau, E. (eds) Animal Cell Technology: From Target to Market. ESACT Proceedings, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0369-8_34
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DOI: https://doi.org/10.1007/978-94-010-0369-8_34
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