Equivalence Testing

  • Ton J. Cleophas
  • Aeilko H. Zwinderman
  • Toine F. Cleophas

Abstract

A study unable to find a difference is not the same as an equivalent study. For example, a study of 3 subjects does not find a significant difference simply because the sample size is too small. Equivalence testing is particularly important for studying the treatment of diseases for which a placebo control would unethical. In the situation a new treatment must be compared with standard treatment. The latter comparison is at risk of finding little differences.

Keywords

Placebo 

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Copyright information

© Springer Science+Business Media Dordrecht 2002

Authors and Affiliations

  • Ton J. Cleophas
    • 1
    • 2
  • Aeilko H. Zwinderman
    • 1
    • 3
  • Toine F. Cleophas
    • 4
  1. 1.European Interuniversity College of Pharmaceutical Medicine LyonFrance
  2. 2.Department MedicineAlbert Schweitzer HospitalDordrechtThe Netherlands
  3. 3.Department Biostatistics and EpidemiologyAcademic Medical Center AmsterdamThe Netherlands
  4. 4.Technical UniversityDelftThe Netherlands

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