Skip to main content

Biodegradable Polymers as Scaffolds for Tissue Engineering and as Tissue Regeneration Inducers

  • Chapter
Polymer Based Systems on Tissue Engineering, Replacement and Regeneration

Part of the book series: NATO Science Series ((NAII,volume 86))

  • 500 Accesses

Abstract

The most powerful treatment to cure diseases may be medication, that is, drug administration to the patients. However, drugs are no more effective when large part of a tissue has been severely damaged or an organ has irreversibly lost its function. In these cases, either artificial organ or organ transplantation is at present the first choice for reconstruction of the defective or lost organ. Unfortunately, these therapeutic methods are not always effective, but have several problems that are difficult to solve. For instance, the number of organ donors is quite smaller than that of the patients waiting for the organ to be transplanted. Complications of immuno-suppresive agents are also trouble for the organ recipients. Also, current artificial organs are required to improve the poor biocompatibility and the insufficient ability to replace defective organs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Petit-Zeman, S. (2001), Regenerative medicine, Nature Biotechnology, 19, 201–206.

    Article  CAS  Google Scholar 

  2. Lanza, R.P., Langer, R., and Vacanti, J. (eds.), (2000), Principles of Tissue Engineering, Second Edition, Academic Press, San Diego.

    Google Scholar 

  3. Caplan, A.I. (2000), Tissue engineering, designs for the future: New logics, old molecules, Tissue Eng., 6, 1–8.

    Article  CAS  Google Scholar 

  4. Chang, S.C.N., Rowley, J.A., Tobias, G., Genes, N.G., Roy, A.K., Mooney, DJ., Vacanti, CA., and Bonassar, L.J. (2001), Injection molding of chondrocyte/alginate constructs in the shape of facial implants, J. Biomed. Mater. Res., 55, 503–511.

    Article  CAS  Google Scholar 

  5. Tsukagoshi, T., Yenidunya, M.O., Sasaki, E., Suse, T., and Hosoda, Y. (1999), Experimental vasucular graft using small-caliver fascia-wrapped fibrocollagenous tube: short-term evaluation, J. Reconstr. Microsurg, 15, 127–131.

    Article  CAS  Google Scholar 

  6. Shinoka, T., Imai, Y., Hibino, N., Watanabe, M., Matsumura, T., Kosaka, Y, Konuma, T., Toyama, S., Yamakawa, M., Ikada, Y., and Morita, S. (2000), Development of blood vessels by tissue engineering using autologuous cells, Artificial Organs (in Japanese), 29, S-25.

    Google Scholar 

  7. Niklason, L.E., Abbott, W., Gao, J., Klagges, B., Hirschi, K.K., Ulubayram, K., Conroy, N., Jones, R., Vasanawala, A., Sanzgiri, S., and Langer, R. (2001), Morphologic and mechanical characteristics of engineered bovine arteries, J. Vasc. Surg., 33, 628–638.

    Article  CAS  Google Scholar 

  8. Kim, B-S. and Mooney, D.J. (2000), Scaffolds for engineering smooth muscle under cyclic mechanical strain conditions, Trans. ASME, 122, 210–215.

    CAS  Google Scholar 

  9. Isner, J.M. and Asahara, T. (2000), Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization, J. Clin. Invest., 103, 1231–1234.

    Article  Google Scholar 

  10. Ikada, Y. (1998), Preface, Adv. Drug. Delivery Reviews, 31, 183–184.

    Article  CAS  Google Scholar 

  11. not yet published.

    Google Scholar 

  12. Suzuki, S., Matsuda, K., Maruguchi, T., Nishimura, Y, and Ikada, Y. (1995). Further applications of “bilayer artificial skin”, British J. Plastic Surgery, 48, 222–229.

    Article  CAS  Google Scholar 

  13. Orlic, D. Kajstura, J. Chimenti, S., Jakoniuk, I., Anderson, S.M., Li, B., Pickel, J., Mckay, R., Nadal-Ginard, B., Bodine, D.M., Leri, A., and Anversa, P. (2001), Bone marow cells regenerate infarcted myocardium, Nature, 410, 701–705.

    Article  CAS  Google Scholar 

  14. Colman, A. (2001), Stem cells-the long march forward to the clinic-, Drug Discovery World Summer, 66–71.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Ikada, Y. (2002). Biodegradable Polymers as Scaffolds for Tissue Engineering and as Tissue Regeneration Inducers. In: Reis, R.L., Cohn, D. (eds) Polymer Based Systems on Tissue Engineering, Replacement and Regeneration. NATO Science Series, vol 86. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0305-6_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-0305-6_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1001-9

  • Online ISBN: 978-94-010-0305-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics