Abstract
The most powerful treatment to cure diseases may be medication, that is, drug administration to the patients. However, drugs are no more effective when large part of a tissue has been severely damaged or an organ has irreversibly lost its function. In these cases, either artificial organ or organ transplantation is at present the first choice for reconstruction of the defective or lost organ. Unfortunately, these therapeutic methods are not always effective, but have several problems that are difficult to solve. For instance, the number of organ donors is quite smaller than that of the patients waiting for the organ to be transplanted. Complications of immuno-suppresive agents are also trouble for the organ recipients. Also, current artificial organs are required to improve the poor biocompatibility and the insufficient ability to replace defective organs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Petit-Zeman, S. (2001), Regenerative medicine, Nature Biotechnology, 19, 201–206.
Lanza, R.P., Langer, R., and Vacanti, J. (eds.), (2000), Principles of Tissue Engineering, Second Edition, Academic Press, San Diego.
Caplan, A.I. (2000), Tissue engineering, designs for the future: New logics, old molecules, Tissue Eng., 6, 1–8.
Chang, S.C.N., Rowley, J.A., Tobias, G., Genes, N.G., Roy, A.K., Mooney, DJ., Vacanti, CA., and Bonassar, L.J. (2001), Injection molding of chondrocyte/alginate constructs in the shape of facial implants, J. Biomed. Mater. Res., 55, 503–511.
Tsukagoshi, T., Yenidunya, M.O., Sasaki, E., Suse, T., and Hosoda, Y. (1999), Experimental vasucular graft using small-caliver fascia-wrapped fibrocollagenous tube: short-term evaluation, J. Reconstr. Microsurg, 15, 127–131.
Shinoka, T., Imai, Y., Hibino, N., Watanabe, M., Matsumura, T., Kosaka, Y, Konuma, T., Toyama, S., Yamakawa, M., Ikada, Y., and Morita, S. (2000), Development of blood vessels by tissue engineering using autologuous cells, Artificial Organs (in Japanese), 29, S-25.
Niklason, L.E., Abbott, W., Gao, J., Klagges, B., Hirschi, K.K., Ulubayram, K., Conroy, N., Jones, R., Vasanawala, A., Sanzgiri, S., and Langer, R. (2001), Morphologic and mechanical characteristics of engineered bovine arteries, J. Vasc. Surg., 33, 628–638.
Kim, B-S. and Mooney, D.J. (2000), Scaffolds for engineering smooth muscle under cyclic mechanical strain conditions, Trans. ASME, 122, 210–215.
Isner, J.M. and Asahara, T. (2000), Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization, J. Clin. Invest., 103, 1231–1234.
Ikada, Y. (1998), Preface, Adv. Drug. Delivery Reviews, 31, 183–184.
not yet published.
Suzuki, S., Matsuda, K., Maruguchi, T., Nishimura, Y, and Ikada, Y. (1995). Further applications of “bilayer artificial skin”, British J. Plastic Surgery, 48, 222–229.
Orlic, D. Kajstura, J. Chimenti, S., Jakoniuk, I., Anderson, S.M., Li, B., Pickel, J., Mckay, R., Nadal-Ginard, B., Bodine, D.M., Leri, A., and Anversa, P. (2001), Bone marow cells regenerate infarcted myocardium, Nature, 410, 701–705.
Colman, A. (2001), Stem cells-the long march forward to the clinic-, Drug Discovery World Summer, 66–71.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Ikada, Y. (2002). Biodegradable Polymers as Scaffolds for Tissue Engineering and as Tissue Regeneration Inducers. In: Reis, R.L., Cohn, D. (eds) Polymer Based Systems on Tissue Engineering, Replacement and Regeneration. NATO Science Series, vol 86. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0305-6_19
Download citation
DOI: https://doi.org/10.1007/978-94-010-0305-6_19
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-1001-9
Online ISBN: 978-94-010-0305-6
eBook Packages: Springer Book Archive