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Computational Simulations of Fluid Flow Dynamics, and Bead Packing in Solid Phase Extraction Microsystems

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Micro Total Analysis Systems 2002

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Abstract

Microchip based Solid-Phase-Extraction (SPE) manifold cartridges were fabricated by Deep Reactive Ion Etching (DRIE) of silicon and packaged in a polymeric housing. Restraining pillars within the manifold system allowed 5 micron packing material to be incorporated. Computational Fluid Dynamics (CFD) simulations of fluid flow around restraining pillars and experimental packing demonstrated that neither pillar geometry nor layout were critical for effective packing but were influential on sample absorption and elution.

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References

  1. Cappiello, A. et al. Micro-SPE method for sample introduction in capillary HPLC/MS, Analytical Chemistry, 73, pp. 298–302, (2001).

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  2. Oleschuk, R. D. et al. Utilization of bead based reagents in microfluidic systems, in A. van den Berg et al. (eds.), Micro Total Analysis Systems 2000, p 11–14, Kluwer Academic Publishers, The Netherlands, (2000).

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Author information

Authors and Affiliations

  1. Laboratory for Applied Microsystems, School of Engineering, Cardiff University, 1-5 The Parade, PO Box 689, Cardiff, CF24 3TF, UK

    Paul D. Senkans & David A. Barrow

  2. GSK R&D, Via Alessandro Fleming 4, Verona, 37135, Italy

    Vern de Biasi

Authors
  1. Paul D. Senkans
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  2. Vern de Biasi
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  3. David A. Barrow
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Editor information

Editors and Affiliations

  1. The University of Tokushima, Tokushima, Japan

    Yoshinobu Baba

  2. Waseda University, Tokyo, Japan

    Shuichi Shoji

  3. University of Twente, Enschede, The Netherlands

    Albert van den Berg

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© 2002 Springer Science+Business Media Dordrecht

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Senkans, P.D., de Biasi, V., Barrow, D.A. (2002). Computational Simulations of Fluid Flow Dynamics, and Bead Packing in Solid Phase Extraction Microsystems. In: Baba, Y., Shoji, S., van den Berg, A. (eds) Micro Total Analysis Systems 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0295-0_25

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  • DOI: https://doi.org/10.1007/978-94-010-0295-0_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3952-9

  • Online ISBN: 978-94-010-0295-0

  • eBook Packages: Springer Book Archive

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