Abstract
We have developed a novel microfluidic device of multiple reactor array that enables quantitative multistep reactions with droplet coalescence. This device consists of three-dimensional microchannel networks fabricated with PDMS, in which nanoliter-sized droplets can be accurately metered and mixed using hydrophobic passive valves and pneumatic pressure. Using this device, single reagent injection is enough to prepare multiple aliquots with precise volume for multiple different reactions or different analyses reducing the influence of evaporation. This type of microarray is applicable for the series of multiple analyses such as clinical blood tests, drug screening or gene discovery.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
K. Hosokawa, T. Fujii and I. Endo, Anal Chem., 71, 4781–4785 (1999)
K. Handique, D.T. Burke, C.H. Mastrangelo and M.A. Burns, Anal. Chem., 72, 4100–4109 (2000)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Yamada, M., Sugiyama, N., Seki, M. (2002). Microfluidic Reactor Array for Multistep Droplet Reactions. In: Baba, Y., Shoji, S., van den Berg, A. (eds) Micro Total Analysis Systems 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0295-0_13
Download citation
DOI: https://doi.org/10.1007/978-94-010-0295-0_13
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3952-9
Online ISBN: 978-94-010-0295-0
eBook Packages: Springer Book Archive