Molecular mechanisms of exon shuffling: illegitimate recombination

van Rijk, Anke; Bloemendal, Hans

doi:10.1007/978-94-010-0229-5_13

Anke van Rijk¹ &
Hans Bloemendal²

Part of the book series: Contemporary Issues in Genetics and Evolution ((CIGE,volume 10))

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1 Citations

Abstract

Illegitimate recombination (IR) is a process that takes place far more often than homologous recombination and is characterized by the recombination between non-homologous or short homologous sequences. The consequences of IR frequently emerge after the introduction of DNA in cell lines because it more frequently integrates in non- homologous than in homologous regions of the host genome. As a result, unexpected truncated or elongated products may be found. By not discarding those products as transfection artifacts, but by studying how they are generated, it might elucidate a possible molecular mechanism of IR. Here we review the current literature describing different mechanisms by which non-homologous DNA recombination can be induced.

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Authors and Affiliations

Department of Human Genetics, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands
Anke van Rijk
Department of Biochemistry, Faculty of Science, University of Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands
Hans Bloemendal

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Anke van Rijk
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M. Long

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van Rijk, A., Bloemendal, H. (2003). Molecular mechanisms of exon shuffling: illegitimate recombination. In: Long, M. (eds) Origin and Evolution of New Gene Functions. Contemporary Issues in Genetics and Evolution, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0229-5_13

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DOI: https://doi.org/10.1007/978-94-010-0229-5_13
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3982-6
Online ISBN: 978-94-010-0229-5
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