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Liver support systems: issues and challenges

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Book cover Encephalopathy and Nitrogen Metabolism in Liver Failure

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Abstract

Artificial liver support has been proposed as a means of treating patients with either acute liver failure or acute exacerbations of underlying chronic liver failure. This approach is based on the assumption that liver support systems can provide temporary support until either the liver recovers or a donor liver becomes available for transplantation. The complexity of the liver is so great and the number of physiologic, biochemical and metabolic functions it performs so large, that no realistic alternative to permanent liver replacement (transplantation) exists. Most currently studied liver support systems are designed to provide temporary liver support.

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Authors and Affiliations

  1. Department of Surgery, Liver Support Unit, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA

    A. A. Demetriou & J. Rozga

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  1. A. A. Demetriou
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  2. J. Rozga
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Editors and Affiliations

  1. Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands

    E. Anthony Jones  & Robert A. F. M. Chamuleau  & 

  2. Department of Biochemistry, Academic Medical Center, Amsterdam, Netherlands

    Alfred J. Meijer

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© 2003 Springer Science+Business Media Dordrecht

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Demetriou, A.A., Rozga, J. (2003). Liver support systems: issues and challenges. In: Jones, E.A., Meijer, A.J., Chamuleau, R.A.F.M. (eds) Encephalopathy and Nitrogen Metabolism in Liver Failure. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0159-5_37

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  • DOI: https://doi.org/10.1007/978-94-010-0159-5_37

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3967-3

  • Online ISBN: 978-94-010-0159-5

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