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Concomitant changes in melatonin metabolism and in hypothalamic histamine in rats with a portacaval anastomosis

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Encephalopathy and Nitrogen Metabolism in Liver Failure

Abstract

Hepatic encephalopathy (HE) is a serious neuropsychiatry complication of acute or chronic liver failure. It is characterized by cognitive and motor disturbances and may progress to hepatic coma. The pathophysiology of HE in chronic liver failure is not well understood.

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References

  1. Cordoba J, Cabrera J, Lataif L, Penev P, Zee P and Blei AT. High prevalence of sleep disturbance in cirrhosis. Hepatology 1998; 27: 339–345.

    Article  PubMed  CAS  Google Scholar 

  2. Steindl PE, Finn B, Bendok B, Rothke S, Zee PC and Blei AT. Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. Ann Intern Med 1995; 123: 274–277.

    PubMed  CAS  Google Scholar 

  3. Steindl PE, Ferenci P and Marktl W. Impaired hepatic catabolism of melatonin in cirrhosis. Ann Intern Med 1997; 127: 494.

    PubMed  CAS  Google Scholar 

  4. Zee PC, Mehta R, Turek FW and Blei AT. Portacaval anastomosis disrupts circadian locomotor activity and pineal melatonin rhythms in rats. Brain Res 1991; 560: 17–22.

    Article  PubMed  CAS  Google Scholar 

  5. Lozeva V, Valjakka A, Anttila E, MacDonald E, Hippelainen M and Tuomisto L. Brain histamine levels and neocortical slow-wave activity in rats with portacaval anastomosis. Hepatology 1999; 29: 340–346.

    Article  PubMed  CAS  Google Scholar 

  6. Lozeva V, Valjakka A, Lecklin A, Olkkonen H, Hippelainen M, Itkonen M, Plumed C and Tuomisto L. Effects of the histamine H(l) receptor blocker, pyrilamine, on spontaneous locomotor activity of rats with long-term portacaval anastomosis. Hepatology 2000; 31: 336–344.

    Article  PubMed  CAS  Google Scholar 

  7. Tuomisto L.:Involvement of histamine in circadian and other rhythms. In: Watanabe T and Wada H, (Eds). Histaminergic Neurons: Morphology and Function. Boca Raton: CRC Press, 1991: 283–295.

    Google Scholar 

  8. Tuomisto L, Lozeva V, Valjakka A and Lecklin A. Modifying effects of histamine on circadian rhythms and neuronal excitability. Behav Brain Res 2001; 124: 129–135.

    Article  PubMed  CAS  Google Scholar 

  9. Nowak JZ. Histamine in the central nervous system: its role in circadian rhythmicity. Acta Neurobiol Exp (Warsz) 1994; 54: 65–82.

    Google Scholar 

  10. Schwartz JC, Arrang JM, Garbarg M, Pollard H and Ruat M. Histaminergic transmission in the mammalian brain. Physiol Rev 1991; 71: 1–51.

    PubMed  CAS  Google Scholar 

  11. Brown RE, Stevens DR and Haas HL. The physiology of brain histamine. Prog Neurobiol 2001; 63:637–672.

    Article  PubMed  CAS  Google Scholar 

  12. Jacobs EH, Yamatodani A and Timmerman H. Is histamine the final neurotransmitter in the entrainment of circadian rhythms in mammals? Trends Pharmacol Sci 2000; 21: 293–298.

    Article  PubMed  CAS  Google Scholar 

  13. Palacios JM, Wamsley JK and Kuhar MJ. The distribution of histamine HI-receptors in the rat brain: an autoradiographic study. Neuroscience 1981; 6: 15–37.

    Article  PubMed  CAS  Google Scholar 

  14. Cote NK and Harrington ME. Histamine phase shifts the circadian clock in a manner similar to light. Brain Res 1993; 613: 149–151.

    Article  PubMed  CAS  Google Scholar 

  15. Mikkelsen JD, Panula P and Moller M. Histamine-immunoreactive nerve fibers in the rat pineal gland: evidence for a histaminergic central innervation. Brain Res 1992; 597: 200–208.

    Article  PubMed  CAS  Google Scholar 

  16. Nowak JZ, Zawilska JB, Woldan-Tambor A, Sek B, Voisin P, Lintunen M and Panula P. Histamine in the chick pineal gland: origin, metabolism, and effects on the pineal function. J Pineal Res 1997; 22: 26–32.

    Article  PubMed  CAS  Google Scholar 

  17. Lozeva V, Anttila E, Tuominen RK, Hippelainen M, Mannisto PT and Tuomisto L. Hypothalamic histamine, growth rate, plasma prolactin and growth hormone levels in rats with long-term portacaval anastomosis. InflammRes 1999; 48: 81–85.

    Article  CAS  Google Scholar 

  18. Prell, GD and Green JP. Measurement of histamine metabolites in brain and cerebrospinal fluid provides insights into histaminergic activity. Agents Actions 1994; 41: C5–C8.

    Article  PubMed  CAS  Google Scholar 

  19. Facciola G, Hidestrand M, von Bahr C and Tybring G. Cytochrome P450 isoforms involved in melatonin metabolism in human liver microsomes. Eur J Clin Pharmacol 2001; 56: 881–888.

    Article  PubMed  CAS  Google Scholar 

  20. Skene DJ, Papagiannidou E, Hashemi E, Snelling J, Lewis DF, Fernandez M and Ioannides C Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices. J Pineal Res 2001; 31: 333–342.

    Article  PubMed  CAS  Google Scholar 

  21. Lauterburg BH, Sautter V, Preisig R and Bircher J. Hepatic functional deterioration after portacaval shunt in the rat. Effects on sulfobromophthalein transport-maximum, indocyanine green clearance and galactose elimination capacity: Gastroenterology 1976; 71: 221–227.

    PubMed  CAS  Google Scholar 

  22. Brzezinski A. Melatonin in humans. N Engl J Med 1997; 336: 186–195.

    Article  PubMed  CAS  Google Scholar 

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Lozeva-Thomas, V. et al. (2003). Concomitant changes in melatonin metabolism and in hypothalamic histamine in rats with a portacaval anastomosis. In: Jones, E.A., Meijer, A.J., Chamuleau, R.A.F.M. (eds) Encephalopathy and Nitrogen Metabolism in Liver Failure. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0159-5_24

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  • DOI: https://doi.org/10.1007/978-94-010-0159-5_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3967-3

  • Online ISBN: 978-94-010-0159-5

  • eBook Packages: Springer Book Archive

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