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Reversal of Fischer’s ratio in an anesthetised porcine model of acute liver failure

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Encephalopathy and Nitrogen Metabolism in Liver Failure
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Abstract

For decades scientists have been experimenting with animal models of fulminant hepatic failure (FHF). They are supposed to provide a controlled experimental environment that is unachievable in clinical practice. An animal model should be reproducible and the species must have metabolic and physiologic pathways similar to those in humans.1

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References

  1. Terblanche J and Hickman R. Animal models of fulminant hepatic failure. Dig Dis Sci 1991; 36: 770–774.

    Article  PubMed  CAS  Google Scholar 

  2. Newsome PN, Henderson NC, Keatch S, Nelson LJ, Fillipi C, Bellamy C, Clutton E, King T, Lee A, Hayes PC and Plevris JN. Development of a fully anaesthetised porcine model of acetaminophren induced acute liver failure. Hepatology 2001; 34: Suppl 2: 486.

    Google Scholar 

  3. Newsome PN, Plevris JN, Nelson LJ and Hayes PC. Animal models of fulminant hepatic failure: A critical evaluation. Liver Transpl 2001; 6: 21–31.

    Google Scholar 

  4. Jalan R, Seery JP, Taylor and Robison SD. Pathogenesis and treatment of chronic hepatic encephalopathy. Ahm Pharm Ther 1996; 10: 681–697.

    Article  CAS  Google Scholar 

  5. Fischer JE, Funovics JM, Aguirre A, James JH, Keane JM, Wesdorp RI, Yoshimura N and Westman T. The role of plasma amino acids in hepatic encephalopathy. Surgery 1975; 78: 276–290.

    PubMed  CAS  Google Scholar 

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© 2003 Springer Science+Business Media Dordrecht

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Dabos, K.J., Newsome, P.N., Plevris, J.N., Hayes, P.C. (2003). Reversal of Fischer’s ratio in an anesthetised porcine model of acute liver failure. In: Jones, E.A., Meijer, A.J., Chamuleau, R.A.F.M. (eds) Encephalopathy and Nitrogen Metabolism in Liver Failure. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0159-5_15

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  • DOI: https://doi.org/10.1007/978-94-010-0159-5_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3967-3

  • Online ISBN: 978-94-010-0159-5

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