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Mechanism of Interaction of Silicon Nitride Powders with Biochemical Media and their Toxic Effect

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Nanostructured Materials and Coatings for Biomedical and Sensor Applications

Part of the book series: NATO Science Series ((NAII,volume 102))

Abstract

For a simulation of toxic effect of silicon nitride powders (in different dispersion state) on human organism, the rates of conversion and mechanisms of interaction with physiological Ringer-Lock solution, gastric juice, blood serum and inorganic media with the same pH were studied. for the alkali and neutral biochemical media, the mechanism of bioinorganic catalysis was established, the Ca2+— ions play the role of catalyst. The results of study were confirmed by toxic tests using a priming of white rats with Si3N4 powders and the further analysis of their blood indexes as well as morphological state of lungs and liver after 1, 3 and 6 months.

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References

  1. T.Ya. Kosolapova, T.V. Andreeva, T.S. Bartnitskaya et al. Non-metallic refractory compounds, Moscow, Metallurgy, 1985 (in Russian).

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  2. A.M. Shevchenko, G.A. Shkurko, O.V. Zagorina, N.V. Boshitskaya, Powder Metallurgy, 1/2 (1994), 117–120 (in Russian).

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  3. K.B. Yatsimirsky, Interaction into the bioinorganical chemistry, Kiev, Naukova dumka, 1976 (in Russian).

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Author information

Authors and Affiliations

  1. Institute for Problems of Materials Science, National Academy of Sciences of Ukraine, 3, Krzhyzhanovsky str., Kiev-142, 03680, Ukraine

    V. A. Lavrenko, N. V. Boshitskaya & G. N. Makarenko

Authors
  1. V. A. Lavrenko
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  2. N. V. Boshitskaya
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  3. G. N. Makarenko
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Editor information

Editors and Affiliations

  1. Department of Materials Engineering, Drexel University, Philadelphia, USA

    Y. G. Gogotsi

  2. Institute for Problems of Materials Science, National Academy of Science, Kiev, Ukraine

    Irina V. Uvarova

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© 2003 Springer Science+Business Media Dordrecht

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Lavrenko, V.A., Boshitskaya, N.V., Makarenko, G.N. (2003). Mechanism of Interaction of Silicon Nitride Powders with Biochemical Media and their Toxic Effect. In: Gogotsi, Y.G., Uvarova, I.V. (eds) Nanostructured Materials and Coatings for Biomedical and Sensor Applications. NATO Science Series, vol 102. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0157-1_6

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  • DOI: https://doi.org/10.1007/978-94-010-0157-1_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1321-8

  • Online ISBN: 978-94-010-0157-1

  • eBook Packages: Springer Book Archive

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