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Assembly of Adhesive Organelles on Gram-Negative Bacteria

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Protein Secretion Pathways in Bacteria

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Abstract

Bacterial pathogens interact with their hosts in a multitude of ways in order to persist, survive and multiply. The molecular signals triggered by these interactions, ultimately determines the fate of the microbe and the consequences to the host. The interaction between a microbe and its host often depends on the presentation of adhesins on the microbial surface. Adhesins are often assembled into hair-like fibers called pili (Fig. 1). Bacterial adhesins bind with stereochemical specificity to host receptors, thus targeting the bacteria to a defined niche within the environment. For example, pili facilitate intimate contact with eukaryotic cells resulting in the colonization of the cell surface, or invasion to gain access to a nutritionally rich environment within the eukaryotic cell allowing evasion of the host defenses. In host-pathogen interactions pili often activate a cascade of events that will ultimately determine whether the microbe will remain extracellular or trigger processes that will allow its uptake into host cells and/or activation of host defense mechanisms.

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  1. Department of Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave., Box 8230, St. Louis, MO, 63110, USA

    Sheryl S. Justice, Karen W. Dodson, Matthew R. Chapman, Michelle M. Barnhart & Scott J. Hultgren

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  1. Department of Molecular Microbiology, Vrije Universiteit Amsterdam, The Netherlands

    Bauke Oudega

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Justice, S.S., Dodson, K.W., Chapman, M.R., Barnhart, M.M., Hultgren, S.J. (2003). Assembly of Adhesive Organelles on Gram-Negative Bacteria. In: Oudega, B. (eds) Protein Secretion Pathways in Bacteria. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0095-6_11

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