Abstract
Small rodents such as mice, rats and guinea pigs are often used for experiments to learn about the influence of some drugs on the visual system, especially for screening purposes. General anesthetics are used, but there are many reports on the influence of anesthetics themselves, such as barbiturates, urethane and others on the ERG (Noell, 1958; Ogawa, 1961; Yonemura et al., 1965; Honda et al., 1972; Van Norren et al., 1977). On the other hand, it is not easy to record stable ERGs in small rodents in vivo without general anesthesia.
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References
Honda, Y. et al. Some observations of the effects of barbiturate upon the Electro retinogram of rabbits. Ophthal Res. 4: 129 (1972).
Noell, W.K. Differentiation, metabolic organization and viability of the visual cell. Arch. Ophthal. 60: 702 (1958).
Norren, D. van, et al. Influence of anesthetics, alcohol and Freon on dark adaptation of monkey cone ERG. Invest. Ophthal. Vis. Sci. 16: 80 (1977).
Ogawa, T. Effects of nembutal on ERG. J. Iwate Med. Assn 13: 822 (1961).
Yonemura, D., et al. Differential vulnerability of the ERG components to pentobarbital. Proc. 4th ISCERG Symposium, p. 155 (1965).
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© 1978 Dr W. Junk b.v. Publishers
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Sugimachi, Y., Inatomi, M., Nakajima, A. (1978). Effect of Anesthetics on Rats’ ERG in vivo. In: François, J., De Rouck, A., Pearlman, J.T., Kelsey, J. (eds) Electrodiagnosis, Toxic Agents and Vision. Documenta Ophthalmologica Proceedings Series, vol 15. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9957-2_5
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DOI: https://doi.org/10.1007/978-94-009-9957-2_5
Publisher Name: Springer, Dordrecht
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