The Mode of Action of Neurotoxins and some Common Chemicals upon the Electrophysiological Properties of Perfused Mammalian Retinas

  • Yoshihito Honda
Part of the Documenta Ophthalmologica Proceedings Series book series (DOPS, volume 15)

Abstract

Prior to the appearance of the in vitro retina as an experimental preparation, intravenous administration of chemicals was a common way of studying retinal toxicology of mammals. However, intravenous administration may bring about unexpected changes in general physiological conditions and is, therefore, limited as a toxicological method. When an in vitro preparation was desired, eyes of cold-blooded animals have been employed. In vitro studies on mammalian retinas originated from a combination of these two approaches; in vivo study of mammalian eyes and in vitro experimentation on tissues from cold-blooded animals.

Keywords

Respiration Diphenylhydantoin Pentobarbital Toxicology Phenobarbital 

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Copyright information

© Dr W. Junk b.v. Publishers 1978

Authors and Affiliations

  • Yoshihito Honda
    • 1
  1. 1.Department of OphthalmologyKyoto UniversitySakyo-kuJapan

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