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Pharmacological Considerations of Current Methods of Therapy

Part of the Current Topics in Veterinary Medicine book series (CTVM, volume 3)

Abstract

The two classes to true anti-inflammatory drugs are (1) glucocorticosteroids and (2) non-steroid (salicylate-like) anti-inflammatory agents. Other classes of drugs which are used as anti-allergics are the sympathomimetics or adrenaline-like compounds and the cromones.

Corticosteroids stabilise cellular and lysosomal membranes and thereby inhibit release of the chemical mediators of inflammation and proteolytic enzymes. Other glucocorticoid effects include inhibition of antibody synthesis; suppression of activity of fibroblasts; elevation of circulating neutrophil count and reduction in eosinophil count. Steroids also increase microvascular tone and decrease permeability thus reducing exudation and oedema formation.

Non-steroid anti-inflammatory drugs (NSAID) act principally to inhibit the biosynthesis of prostaglandine. The salicylate-like compounds also inhibit kallikrein activity and kinin formation and at the same time pharmacologically antagonise the tissue effects of kinins, prostaglandine and slow-reacting substance of anaphylaxis (SRS-A). NSAID are, with some exceptions, analgesic and antipyretic: effects not shown by corticosteroids.

The glucocorticoids have been utilised extensively in acute and chronic inflammation, particularly in afflictions of the skin, musculo-skeletal system and lung. These drugs are of no value in acute anaphylaxis or histamine stock. Salicylate-like drugs are used mainly for musculo-skeletal disorders. NSAID have been shown to be effective in controlling respiratory hypersensitivity in cattle and horses and are worthy of greater prominence in this respect. Adrenaline and related drugs are most often employed in situations involving allergic respiratory and cardiovascular impairment. Cromones, which prevent release of histamine, have not been employed in clinical veterinary medicine.

Keywords

Migration Inhibitory Factor Oedema Formation Mefenamic Acid Disodium Cromoglycate Prostaglandin Endoperoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barlow, J.E. and Rosenthal, A.S. 1973. Glucocorticoid suppression of macrophage migration inhibitory factor. Journal of Experimental Medicine, 137, 1031–1039.CrossRefGoogle Scholar
  2. Bunting, S., Gryglewski, R., Moncada, S. and Vane, J.R. 1976. Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strip of mesenteric and coeliac arteries and inhibits platelet aggregation. Prostaglandins, 12, 897–913.PubMedCrossRefGoogle Scholar
  3. Burka, J.F. and Eyre, P. 1977. Effects of bovine SRS-A (SRS-Abov) on bovine respiratory tract and lung vasculature in vitro. European Journal of Pharmacology, 44, 169–177.PubMedCrossRefGoogle Scholar
  4. Chand, N. and Eyre, P. 1977. Non-steroidal anti-inflammatory drugs; A revièw. New applications in hypersensitivity reactions of cattle and horses. Canadian Journal of Comparative Medicine, 41, 233–240.PubMedGoogle Scholar
  5. Eyre, P. 1977. Pharmacology of bovine, pulmonary vein anaphylaxis in vitro. British Journal of Pharmacology, 43, 302–311.Google Scholar
  6. Eyre, P. 1976. Preliminary studies on the antagonism of anaphylactic hypersensitivity in the horse. Canadian Journal of Comparative Medicine, 40, 149–152.PubMedGoogle Scholar
  7. Eyre, P., Lewis, A.J. and Wells, P.W. 1973. Acute systemic anaphylaxis in the calf. British Journal of Pharmacology, 47, 504–516.PubMedGoogle Scholar
  8. Eyre, P., Nymeyer, D.H., McCraw, B.M. and Delin, T.R. 1976. Protection by acetylsalicylic acid (Aspirin) and other agents in experimental acute interstitial pneumonia of calves. Veterinary Record, 98, 64–66.PubMedCrossRefGoogle Scholar
  9. Ferriera, S.H. and Vane, J.R. 1974. New aspects of the mode of action of non-steroid anti-inflammatory drugs. Annual Review of Pharmacology, 14, 57–73.CrossRefGoogle Scholar
  10. Gryglewski,R.J., Bunting, S., Moncada, S., Flower, R.J. and Vane, J.R. 1976. Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins, 12, 685–713.CrossRefGoogle Scholar
  11. Kuehl, F.A., Humes, J.L., Egan, R.W., Ham, E.A., Beveridge, G.C., and Van Arman, C.G. 1977. Role of prostaglandin endoperoxide PGG2 in inflammatory process. Nature (London), 265, 170–172.CrossRefGoogle Scholar
  12. Moncada, S., Needleman, P., Bunting, S. and Vane, J.R. 1976. Prostaglandin endoperoxide and thromboxane-generating systems and their selective inhibition. Prostaglandins, 12, 323–335. 416Google Scholar
  13. Vane, J.R. 1971. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature (London), 231, 232–235.Google Scholar

Copyright information

© ECSC, EEC, EAEC, Brussels-Luxembourg 1978

Authors and Affiliations

  • P. Eyre
    • 1
  1. 1.Ontario Veterinary CollegeUniversity of GuelphCanada

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