Effect of Autonomic Activity on Pacemaker Function and Conduction
The effect of the autonomic nervous system on impulse formation and conduction within the heart is well known. The time course of the effect of a brief vagal volley on sinus node cycle length was first measured by Brown and Eccles in 1934 (93). Subsequent workers described the discrete effect of phasic changes in vagal tone on spontaneous sinus rhythm in both animals and man during complete atrioventricular conduction block (40,443,448, 490,685). Several laboratories have defined the time course of autonomic stimulation on atrioventricular conduction (186,542,778,872), however there have been few studies concerning the role of phasic variations in autonomic tone on arrhythmia production. The present studies describe effects of phasic stimulation of the sympathetic and parasympathetic nervous system upon atrioventricular conduction in the anesthetized open-chest dog.
Unable to display preview. Download preview PDF.
© Martinus Nijhoff Medical Division 1978