Function and Dysfunction of the Sinus Node: Clinical Studies in the Evaluation of Sinus Node Function

  • Jay L. Jordan
  • Iwao Yamaguchi
  • William J. Mandel


The sick sinus syndrome is a descriptive term coined by Lown (1966) and popularized by Ferrer (1968), referring to a constellation of clinical signs, symptoms, and electrocardio-graphic (ECG) criteria defining sinus node dysfunction. The syndrome is characterized by syncope or other manifestations of cerebral dysfunction in association with sinus brady-cardia, sinus arrest, sinoatrial block, alternating bradyarrhythmias and tachyarrhythmias and/or carotid hypersensitivity. Clinical signs and symptoms, however, result from failure of escape pacemaker function not from sinus node malfunction per se (Mandel and Laks, 1974); thus, the sick sinus syndrome may represent a generalized disorder of the conduc- tion system.


Sinus Node Sick Sinus Syndrome Sinus Node Dysfunction Overdrive Pace Sinus Node Function 
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© Martinus Nijhoff Medical Division 1978

Authors and Affiliations

  • Jay L. Jordan
  • Iwao Yamaguchi
  • William J. Mandel

There are no affiliations available

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