Skip to main content

Anterior Fusiform Cataract (Cat-B): A New Type of Recessively Inherited Lens Opacity in the Sprague Dawley Rat

  • Chapter
Progress in Anterior Eye Segment Research and Practice

Abstract

A new mutant Sprague Dawley rat is described, in which the occurrence of bilateral nuclear lens opacities with a fusiform or pyramidal connection to the anterior lens pole (cat-b) is a recessively inherited trait. The gene has about 99% penetrance and a slight variation in expression. During lens development the opaque nucleus-pole connection eventually becomes disrupted so that all animals have mere nuclear cataracts, when they reach the age of 100 days. Lens fresh weights are reduced in affected animals under the age of 16 days.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baumgarten, H. Versuche zur experimentellen Rötelnembryopathie bei der Ratte. Diplomarbeit: Bonn (1977).

    Google Scholar 

  • Bourne, M.C. & Grüneberg, H. Degeneration of the retina and cataract A new recessive gene in the rat (rattus norvegicus). J. Heredity 30: 131–136 (1939).

    Google Scholar 

  • Gorthy, W.C. & Abdelbaki, Y.Z. Morphology of a hereditary cataract in the rat. Expl. Eye Res. 19: 147–156 (1974).

    Article  CAS  Google Scholar 

  • Hess, v. Zur Pathologie und pathologischen Anatomie verschiedener Starformen. Cataracta centralis, Cataracta perinuclearis. — Zur Erklärung der angeborenen Cata-ractformen. — Cataracta punctata. Albrecht v. Graefes Arch. Ophthal. 39, I: 183–220 (1893).

    Google Scholar 

  • Jess, A. Über kongenitale und vererbbare Staarformen der weißen Ratte nebst Bemerkungen über die Frage des Verhaltens der Linsen bei vitaminfreier Ernährung. Klin. Mbl. Augenheilk. 74: 49–56 (1925).

    Google Scholar 

  • Kern, R. & Schäfer, K. Über eine angeborene Katarakt der Ratte. I: Linsenveränderungen während der ersten 14 Tage. Ophthalmologica 161: 255–263 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Koch, H.-R., Fischer, A. & Kaufmann, H. Occurrence of cataracts in spontaneously Ophthal. 1: 55–62 (1976).

    Google Scholar 

  • Koch, H.-R., Fischer, A. & Kaufmann, H. Occurrence of cataracts in spontaneously hypertensive rats. Ophthal. Res. 9: 189–193 (1977).

    Article  Google Scholar 

  • Lambert, W.V. & Sciuchetti, A. A dwarf mutation in the rat. Science 81: 278 (1935).

    Article  PubMed  CAS  Google Scholar 

  • Léonard, A. & Maisin, J.R. Hereditary cataract induced by X-irradiation of young rats. Nature 205: 615–616 (1965).

    Article  PubMed  Google Scholar 

  • Lisch, K. Zur Genese des vorderen Polstars. Graefes Arch. Ophthal. 145: 393–396 (1943).

    Google Scholar 

  • Mann, I. Developmental abnormalities of the eye. University Press: Cambridge (1937).

    Google Scholar 

  • Smith, S.E. & Barrentine, B.F. Hereditary cataract. A new dominant gene in the rat. J. Hered. 34: 8–16 (1943).

    Google Scholar 

  • Smith, R., Hoffman, H. & Cisar, C. Congenital cataract in the rat. Arch. Ophthal., Chicago 81: 259–263 (1969).

    CAS  Google Scholar 

  • Vogt, A. Vorderer Polstar bei Schichtstar. In: Lehrbuch und Atlas der Spaltlampenmikroskopie des lebenden Auges. Vol. 2, p. 407. Springer: Berlin (1931) p. 407.

    Google Scholar 

  • Waardenburg, P.J. The lens, in, Genetics and Ophthalmology. Vol. 1, p. 847–951. Van Gorkum: Assen (1961).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

O. Hockwin W. B. Rathbun

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Dr W. Junk b.v. Publishers

About this chapter

Cite this chapter

Koch, HR., Baumgarten, H., Kratochvilova, J. (1979). Anterior Fusiform Cataract (Cat-B): A New Type of Recessively Inherited Lens Opacity in the Sprague Dawley Rat. In: Hockwin, O., Rathbun, W.B. (eds) Progress in Anterior Eye Segment Research and Practice. Documenta Ophthalmologica Proceedings Series, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9609-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-9609-0_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-6193-158-4

  • Online ISBN: 978-94-009-9609-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics