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Chemical Burn of the Rabbit Cornea Morphometric Studies of the Corneal Stroma

  • Y. Pouliquen
  • J. P. Giraud
  • M. Hirsch
  • G. Renard
  • M. Cordova
  • M. Savoldelli
  • O. Marquet
Conference paper
Part of the Documenta Ophthalmologica Proceedings Series book series (DOPS, volume 20)

Abstract

In the rabbit, the corneal burn with a Na OH, 0,5 N solution lead to a diffuse but crowded and durable opacity of this cornea. The ultrastructural observation of this corneal stroma with time shows apparent changes in the fibrillar diameters, alterations of the centered hexagonal fibrillar stacking, with an increase of the interfibrillar distances or sometimes, an agglutination of neighbour fibrils.

But the quantitative study only allows a significant gathering of these facts and reveals that during the first 30 days, the homogeneity is preserved as for the mean fibrillar diameter: 300 ± 85 Å (normal 300 ± b 50 Å).

After the 30th day, the mean value remains approximately the same but with a standard deviation more than 2 times higher, showing an actual heterogeneity: 300 ± 200 Å particularly in the anterior part of the cornea.

The interfibrillar distances inclusively, are generally greater than normally: 625 ± 200 Å, specially during the three first weeks after the burn. However, there exist some zones where the normal fibrillar arrangement is maintened: 540 ± 100 Å, even in the earliest stages. Some lakefree zones are observed.

At last, a small difference between the anterior and posterior parts of the injury is pointed out.

Keywords

Corneal Stroma Corneal Lesion Anterior Stroma Posterior Stroma Significant Gathering 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Giraud, J.P., Y. Pouliquen, G. Offret & P. Payrau. Statistical Morphometric Studies in Normal Human an Rabbit Corneal Stroma. Exp. Eye Res. 21: 221–229, (1975).Google Scholar
  2. Renard, G., M. Hirsch, O. Marquet & Y. Pouliquen. Scanning and transmission electron microscopic study of alkaliburned cornea. Association for Eye Research, 17th meeting Guilford 8–12 Sept., 1976.Google Scholar

Copyright information

© Dr W. Junk bv Publishers 1979

Authors and Affiliations

  • Y. Pouliquen
    • 1
  • J. P. Giraud
    • 1
  • M. Hirsch
    • 1
  • G. Renard
    • 1
  • M. Cordova
    • 1
  • M. Savoldelli
    • 1
  • O. Marquet
    • 1
  1. 1.Laboratoire de la Clinique Ophtalmologique de l’Hotel DieuParisFrance

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