Skip to main content
SpringerLink
Log in

Studies on Complexes of Antineoplastic Agents with DNA

  • Chapter
Optically Active Polymers

Part of the book series: Charged and Reactive Polymers ((CHRP,volume 5))

  • 212 Accesses

Abstract

Aspects of the geometry of complexes between antineoplastic agents and DNA can be determined using hydrodynamic measurements and using the technique of Electric Dichroism. Data is presented for two compounds, anthramycin and ellipticine, which shows that ellipticine binds to DNA by intercalation while anthramycin does not, the chromophore portion of the anthramycin molecule being inclined at an angle of approximately 36° with respect to the helix axis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adamson, R. H., Hart, L. G., Devita, V. T., and Oliverio, V. T.: Cancer Res. 28, 343 (1968).

    CAS  Google Scholar 

  2. Cohen, G. and Einberg, H.: Biopolymers 8, 45 (1969).

    Article  CAS  Google Scholar 

  3. Craig, M. and Isenberg, I,: Biopolymers 9, 689 (1970).

    Article  CAS  Google Scholar 

  4. Eigner, J. and Doty, P.: J. Mol Biol. 12, 549 (1965).

    Article  CAS  Google Scholar 

  5. Hartwell, J. and Abbott, B.: Adv. Chemother. Phannacol. 7, 117 (1969).

    CAS  Google Scholar 

  6. Kohn, K. W., Bono, V. H., Jr„ and Kann, H. E., Jr.: Biochem. Biophys. Acta 155. 121 (1968).

    CAS  Google Scholar 

  7. Kohn, K. W., Glaubiger, D., and Spears, C. L.: Biochem. Biophys Acta 361, 288 (1974).

    CAS  Google Scholar 

  8. Kohn, K. W. and Spears, C. L.: J. Mol. Biol 51, 48 (1970).

    Article  Google Scholar 

  9. Lerman, L. S.: Proc. Nat. Acad. Sci. US. 49, 94 (1963).

    Article  CAS  Google Scholar 

  10. Lerman, L. S.: J. Cell Comp. Physiol 64 (Suppl. 1). 1 (1964).

    Article  CAS  Google Scholar 

  11. Muller, W. and Crothers, D. M.: J Mol Biol. 35, 251 (1968)

    Article  CAS  Google Scholar 

  12. Richards, O. C. and Boyer, P. D: J Mol Biol. 11, 327 (1965).

    Article  CAS  Google Scholar 

  13. Tendler, M. D. and Korinan, S.: Nature 199, 501 (1963).

    Article  CAS  Google Scholar 

  14. Yamaoka, K. and Charney. E.: J. Am. Chem. Sci. 94, 8963 (1972).

    Article  CAS  Google Scholar 

  15. Yamaoka, K. and Charney, E.: Macromol. 6, 66 (1973).

    Article  CAS  Google Scholar 

  16. Waring, M.: J. Mol Biol 54, 247 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Stanford University Medical Center, Calif., USA

    Daniel Glaubiger

Authors
  1. Daniel Glaubiger
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Université de Rouen, France

    Eric Selegny

Rights and permissions

Reprints and permissions

Copyright information

© 1979 D. Reidel Publishing Company

About this chapter

Cite this chapter

Glaubiger, D. (1979). Studies on Complexes of Antineoplastic Agents with DNA. In: Selegny, E. (eds) Optically Active Polymers. Charged and Reactive Polymers, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9378-5_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-9378-5_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-9380-8

  • Online ISBN: 978-94-009-9378-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation