Studies on Complexes of Antineoplastic Agents with DNA

  • Daniel Glaubiger
Part of the Charged and Reactive Polymers book series (CHRP, volume 5)

Abstract

Aspects of the geometry of complexes between antineoplastic agents and DNA can be determined using hydrodynamic measurements and using the technique of Electric Dichroism. Data is presented for two compounds, anthramycin and ellipticine, which shows that ellipticine binds to DNA by intercalation while anthramycin does not, the chromophore portion of the anthramycin molecule being inclined at an angle of approximately 36° with respect to the helix axis.

Keywords

Obesity Filtration Phenol EDTA Leukemia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adamson, R. H., Hart, L. G., Devita, V. T., and Oliverio, V. T.: Cancer Res. 28, 343 (1968).Google Scholar
  2. 2.
    Cohen, G. and Einberg, H.: Biopolymers 8, 45 (1969).CrossRefGoogle Scholar
  3. 3.
    Craig, M. and Isenberg, I,: Biopolymers 9, 689 (1970).CrossRefGoogle Scholar
  4. 4.
    Eigner, J. and Doty, P.: J. Mol Biol. 12, 549 (1965).CrossRefGoogle Scholar
  5. 5.
    Hartwell, J. and Abbott, B.: Adv. Chemother. Phannacol. 7, 117 (1969).Google Scholar
  6. 6.
    Kohn, K. W., Bono, V. H., Jr„ and Kann, H. E., Jr.: Biochem. Biophys. Acta 155. 121 (1968).Google Scholar
  7. 7.
    Kohn, K. W., Glaubiger, D., and Spears, C. L.: Biochem. Biophys Acta 361, 288 (1974).Google Scholar
  8. 8.
    Kohn, K. W. and Spears, C. L.: J. Mol. Biol 51, 48 (1970).CrossRefGoogle Scholar
  9. 9.
    Lerman, L. S.: Proc. Nat. Acad. Sci. US. 49, 94 (1963).CrossRefGoogle Scholar
  10. 10.
    Lerman, L. S.: J. Cell Comp. Physiol 64 (Suppl. 1). 1 (1964).CrossRefGoogle Scholar
  11. 11.
    Muller, W. and Crothers, D. M.: J Mol Biol. 35, 251 (1968)CrossRefGoogle Scholar
  12. 12.
    Richards, O. C. and Boyer, P. D: J Mol Biol. 11, 327 (1965).CrossRefGoogle Scholar
  13. 13.
    Tendler, M. D. and Korinan, S.: Nature 199, 501 (1963).CrossRefGoogle Scholar
  14. 14.
    Yamaoka, K. and Charney. E.: J. Am. Chem. Sci. 94, 8963 (1972).CrossRefGoogle Scholar
  15. 15.
    Yamaoka, K. and Charney, E.: Macromol. 6, 66 (1973).CrossRefGoogle Scholar
  16. 16.
    Waring, M.: J. Mol Biol 54, 247 (1970).CrossRefGoogle Scholar

Copyright information

© D. Reidel Publishing Company 1979

Authors and Affiliations

  • Daniel Glaubiger
    • 1
  1. 1.Department of PediatricsStanford University Medical CenterUSA

Personalised recommendations