Abstract
It is now more than 10 years that BURNET published his hypothesis on the pathogenesis of SSPE (1). BURNET assumed that the underlying defect was a specific unresponsiveness at the level of T cells. Despite a large body of experimental data (reviewed in (2)) this hypothesis cannot be conclusively answered at present. It is also evident that the mode of action of specific T cells during acute measles itself is incompletely understood. This may be at least partly due to the difficulties in designing appropriate in vitro experiments which explore conclusively specific T cell immunity in man.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Burnet, FM: Measles as an index of immunological function. Lancet ii: 610–613, 1968.
Agnarsdottir, G: Subacute sclerosing panencephalitis. Recent Adv Clin Virol 1: 21–49, 1977.
Simpson, E, PC Beverley: T cell subpopulations. In: Progress in Immunology, III, Amsterdam, North-Holland, 1977, p 206–214.
Burns, WH, LC Billups, AL Notkins: Thymus dependence of viral antigens. Nature 256: 654–655, 1975.
Valdimarsson, H, G Agnarsdottir, PJ Lachmann: Cellular immunity in subacute sclerosing panencephalitis. Proc Roy Soc Med 67: 1125–1129, 1974.
Kreth, HW, YM Kaeckell, V ter Meulen: Cellular immunity in SSPE patients. Med Microbiol Immunol 160: 191–199, 1974.
Steele, WR, DA Fuccillo, SA Hensen, MM Vincent, JA Bellanti: Specific inhibitory factors of cellular immunity in children with subacute panencephalitis. J Pediat 88: 56–62, 1976.
Perrin, LM, A Tishon, MBA Oldstone: Immunologic injury in measles virus infection. III. Presence and characterization of human cytotoxic lymphocytes. J Immunol 118: 282–290, 1977.
Ewan, PW, PJ Lachmann: Demonstration of T cell and K cell cytotoxicity against measles-infected cells in normal subjects, multiple sclerosis and subacute sclerosing panencephalitis. Clin Exp Immunol 30: 22–31, 1977.
Norrby, E: A carrier cell line of measles virus in Lu 106 cells. Arch ges Virusforsch 20: 215–224, 1967.
Kreth, HW, G Wiegand: Cell-mediated cytotoxicity against measles virus in SSPE. II. Analysis of cytotoxic effector cells. J Immunol 118: 296–301, 1977.
Morales, A, GD Bonnard, M Dean, JH Herbermann: In vitro augmentation of natural killer (NK) and antibody-dependent killer (K) cell activities by co-cultivation with mumps virus. (Abstract) Fed Proc 36: 1325, 1977.
Trinchieri, G, D Santoli: Anti-viral activity induced by lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis. J exp Med 147: 1314–1333.
Santoli, D, G Trinchieri, FS Lief: Cell-mediated cytotoxicity against virus-infected target cells in humans. I. Characterization of the effector lymphocyte. J Immunol 121: 526–531, 1978.
Kall, MA, HS Koren: Heterogeneity of natural killer cell populations. Cell Immunol 40: 58–68, 1978.
Doherty, PC, RV Blanden, RM Zinkernagel: Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions. Implication for H2-antigen diversity. Transpl Rev 29: 89–124, 1975.
Kreth, HW, V ter Meulen, G Eckert: Demonstration of HLA restricted killer cells in patients with acute measles. Med Microbiol Immunol 165: 203–214, 1979.
Galama, JMD, CT Lucas, A Vos: Lymphocyte-mediated cytotoxicity to cells infected with measles virus. I. Use of in vitro infected leukocytes as autologous target cells; absence of virus-specific cytotoxic lymphocytes. Cell Immunol 38: 365–377, 1978.
Kedar, E, M Ortiz de Landazuri, B Bonavida: Cellular immunoadsorbents: A simplified technique for separation of lymphoid cell populations. J Immunol 112: 1231–1243, 1974.
Ertl, M, M Koszinowski: Cell-mediated cytotoxicity against Sendai-virus-infected cells. Z Immun Forsch 152: 128–140, 1975.
Eijsvoogel, VP, TA Schellekens, MJGJ Du Bois, WP Zeijlemaker: Human cytotoxic lymphocytes after alloimmunization in vitro. Transplant Rev 29: 125–145, 1975.
Dunlop, MBC, RV Blanden: Secondary cytotoxic cell response to lymphocytic choriomeningitis. I. Kinetics of induction in vitro and yields of effector cells. Immunol 31: 171–180, 1976.
McMichael, AJ, B Askonas:“Influenza virus-specific cytotoxic T cells in man: induction and properties of the cytotoxic cell. Europ J Immunol 8: 711–715, 1978.
Biddison, WE, S Shaw, DL Nelson: Virus specificity of human influenza virus-immune cytotoxic T cells. J Immunol 122: 660–664, 1979.
Gmelig-Meyling, F, RE Ballieux: Simplified procedure for the separation of human T and non-T cells. Vox Sang 33: 5–8, 1977.
Moretta, L, M Ferrarini, MC Mingari, A Moretta, SR Webb: Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness. J Immunol 117: 2171–2174, 1976.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Kreth, W., Pabst, F. (1979). Recent Findings on Cell — Mediated Immune Reactions in Acute Measles and SSPE. In: Tyrrell, D.A.J. (eds) Aspects of Slow and Persistent Virus Infections. New Perspectives in Clinical Microbiology, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9339-6_8
Download citation
DOI: https://doi.org/10.1007/978-94-009-9339-6_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-9341-9
Online ISBN: 978-94-009-9339-6
eBook Packages: Springer Book Archive