Skip to main content

Infectious Complications in Maintenance Dialysis Patients

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

Prior to the advent of chronic hemodialysis, infection was frequently a terminal or preterminal event in patients with end-stage renal failure. During the last decade, better hemodialysis techniques coupled with general advances in medical therapy have improved the prognosis (1–3). However, infectious complications continue to be a major medical threat to patients receiving maintenance hemodialysis (4–7). It is unquestionable that the most common type of infections are those related to the blood access device. In this chapter we will review incidence and type of infectious complications that occur in patients undergoing chronic hemodialysis, both as documented in the literature and as determined by us in a survey of 445 patients. It seems important to emphasize at the beginning that most of the infections seen in patients with severe renal failure can be accounted for by commonly occurring bacteria and not by unusual or opportunistic organisms. The repetitive exposure of these patients to infectious risk factors during hemodialysis appears of major importance in determining the infectious complications observed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gross JB, Keane WF, McDonald AK: Survival and rehabilitation of patients on home hemodialysis. Ann Intern Med 78: 341, 1973

    PubMed  CAS  Google Scholar 

  2. Burton BT, Krueger KK, Bryan FA Jr: National registry of long-term dialysis patients. JAMA 218: 718, 1971

    Article  PubMed  CAS  Google Scholar 

  3. Lewis EJ, Foster DM, de la Puente J, Scurlock C: Survival data for patients undergoing chronic intermittent hemodialysis. Ann Intern Med 70: 311, 1969

    PubMed  CAS  Google Scholar 

  4. Montgomerie JZ, Kalmanson GM, Guze LB: Renal failure and infection. Medicine 47: 1, 1968

    Article  PubMed  CAS  Google Scholar 

  5. Blagg CR, Hickman RO, Eschbach JW, Scribner BH: Home hemodialysis: Six years experience. N Engl J Med 283: 1126, 1970

    Article  PubMed  CAS  Google Scholar 

  6. Gurland HJ, Brunner FP, v Dehn H, Harlen H, Parsons FM, Scharer K: Combined report on regular dialysis and transplantation in Europe III, 1972. Proc Eur Dial Transpl Assoc 10: XVII, 1973

    Google Scholar 

  7. Lowrie EG, Lazarus JM, Mogelin AJ, Bailey GL, Hampers CL, Wilson RE, Merrill JP: Survival of patients undergoing chronic hemodialysis and renal transplantation. N Engl J Med 288: 863, 1973

    Article  PubMed  CAS  Google Scholar 

  8. Dammin GJ, Couch NP, Murray JE: Prolonged survival of skin homografts in uremic patients. Ann NY Acad Sci 64: 967, 1957

    Article  PubMed  CAS  Google Scholar 

  9. Mannick JA, Powers JH, Mithoefer J, Ferrebee JW: Renal transplantation in azotemic dogs. Surgery 47: 340, 1960

    PubMed  CAS  Google Scholar 

  10. Morrison AB, Maness K, Tawes R: Skin homograft survival in chronic renal insufficiency. Arch Pathol 75: 139, 1963

    CAS  Google Scholar 

  11. Wilson WEC, Kirkpatrick CH, Talmage DW: Suppression of immunologic responsiveness in uremia. Ann Intern Med 62: 1, 1965

    Google Scholar 

  12. Jordan MC, Rousseau WE, Tegtmeier GE, Noble GR, Muth RG, Chin TDY: Immunogenicity of inactivated influenza virus vaccine in chronic renal failure. Ann Intern Med 79: 790, 1973

    PubMed  CAS  Google Scholar 

  13. Stoloff IL, Stout R, Myerson RM, Havens WP Jr: Production of antibody in patients with uremia. N Engl J Med 259: 320, 1958

    Article  PubMed  CAS  Google Scholar 

  14. Spencer ES: Cytomegalovirus antibody in uremic patients prior to renal transplantation. Scand J Infect Dis 6: 1, 1974

    PubMed  CAS  Google Scholar 

  15. Kauffman CA, Manzler AD, Phair JP: Cell-mediated immunity in patients on long-term haemodialysis. Clin Exp Immunol 22: 54, 1975

    PubMed  CAS  Google Scholar 

  16. Newberry WM, Sanford JP: Defective cellular immunity in renal failure: Depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum. J Clin Invest 50: 1262, 1971

    Article  PubMed  CAS  Google Scholar 

  17. Touraine JL, Touraine F, Revillard JP, Brochier J, Traeger J: T-lymphocytes and serum inhibitors of cell- mediated immunity in renal insufficiency. Nephron 14: 195, 1975

    Article  PubMed  CAS  Google Scholar 

  18. Harris J, Sengar D, Rashid A, Hyslop D, Green L, Goldstein AL: Immunodeficiency in chronic uremia. Transplantation 20: 176, 1975

    Article  PubMed  CAS  Google Scholar 

  19. Hurst KS, Saldanha LF, Steinberg SM, Galen MA, Lourie EG, Gagneux SA, Lazarus JM, Strom TB, Carpenter CB, Merrill JP: The effects of varying dialysis regimens on lymphocyte stimulation. Trans Am Soc Artif Intern Organs 21: 329, 1975

    PubMed  CAS  Google Scholar 

  20. Sengar D, Rashid A, Perelmutter L, Harris JE: Lymphocytotoxins and mixed leucocyte culture blocking factor activity in the plasma of uraemic patients undergoing haemodialysis. Clin Exp Immunol 20: 249, 1975

    PubMed  CAS  Google Scholar 

  21. Selroos O, Pasternack A, Virolainen M: Skin test sensitivity and antigen induced lymphocyte transformation in uraemia. Clin Exp Immunol 14: 365, 1973

    PubMed  CAS  Google Scholar 

  22. Kasakura S, Lowenstein L: The effect of uremic blood on mixed leukocyte reactions and on cultures of leukocytes with phytohemagglutinin. Transplantation 5: 283, 1967

    Article  Google Scholar 

  23. Sanders CV Jr, Luby JP, Sanford JP, Hull AR: Suppression of interferon responses in lymphocytes from patients with uremia. J Lab Clin Med 77: 768, 1971

    PubMed  CAS  Google Scholar 

  24. Sengar D, Rashid A, Harris J: In vitro cellular immunity and in vivo delayed hypersensitivity in uremic patients maintained on hemodialysis. Int Arch Allergy Appl Immunol 47: 829, 1974

    Article  PubMed  CAS  Google Scholar 

  25. Guckian JC, Karrh LR, Copeland JL, McCoy J: Phagocytosis by polymorphonuclear leukocytes in patients with renal failure on chronic hemodialysis. Tex Rep Biol Med 29: 193, 1971

    PubMed  CAS  Google Scholar 

  26. Brogan TD: Phagocytosis by polymorphonuclear leucocytes from patients with renal failure. Br Med J 3: 596, 1967

    Article  Google Scholar 

  27. Chreitien JH, Garagusi VF: Phagocytosis and nitroblue tetrazolium reduction in uremia. Experientia 29: 612, 1973

    Article  Google Scholar 

  28. Baum J, Cestero RVM, Freeman RB: Chemotaxis of the polymorphonuclear leukocyte and delayed hypersensitivity in uremia. Kidney Int 7, 1 (suppl 2): SI47, 1975

    Google Scholar 

  29. Lang PA, Ritzmann SE, Merian FL, Lawrence MC, Levin WC, Gregory R: Cellular evolution in induced inflammation in uremic patients. Tex Rep Biol Med 24: 107, 1966

    PubMed  CAS  Google Scholar 

  30. Buchanan WW, Klinenberg JR, Seegmiller JE: The inflammatory response to injected microcrystalline mono- sodium urate in normal, hyperuricemic, gouty and uremic subjects. Arthritis Rheum 8: 361, 1965

    Article  PubMed  CAS  Google Scholar 

  31. London WT, DiFiglia M, Sutnick AI, Blumberg BS: An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med 281: 571, 1969

    Article  PubMed  CAS  Google Scholar 

  32. Greenberg HB, Pollard RB, Lutwick LI, Gregory PB, Robinson WS, Merigan TC: Human leukocyte interferon and hepatitis B virus infection. N Engl J Med 295: 517, 1976

    Article  PubMed  CAS  Google Scholar 

  33. Lopez C, Simmons RL, Mauer SM, Najarian JS, Good RA: Association of renal allograft rejection with virus infections. Am J Med 56: 280, 1974

    Article  PubMed  CAS  Google Scholar 

  34. Comty CM, Cohen SL, Shapiro FL: Pericarditis in chronic uremia and its sequels. Ann Intern Med 75: 173, 1971

    PubMed  CAS  Google Scholar 

  35. Bailey GL, Hampers CL, Hager EB, Merrill JP: Uremic pericarditis: Clinical features and management. Circulation 38: 582, 1968

    PubMed  CAS  Google Scholar 

  36. Scrimshaw NS, Taylor CE, Gordon JE: Interactions of nutrition and infection. WHO Monogr Ser 57, 1968

    Google Scholar 

  37. Douglas SD, Schopfer K: Phagocyte function in protein-calorie malnutrition. Clin Exp Immunol 17: 121, 1974

    PubMed  CAS  Google Scholar 

  38. Schopfer K, Douglas SD: Neutrophil function in children with kwashiorkor. J Lab Clin Med 88: 450, 1976

    PubMed  CAS  Google Scholar 

  39. Comty CM, Wathen RL, Shapiro FL: Protein metabolism in renal failure. Urology 1: 528, 1973

    Article  PubMed  CAS  Google Scholar 

  40. Gulyassy PF, Aviram A, Peters JH: Evaluation of amino acid and protein requirements in chronic uremia. Arch Intern Med 126: 855, 1970

    Article  PubMed  CAS  Google Scholar 

  41. Aviram A, Peters JH, Gulyassy PF: Dialysance of amino acids and related substances. Nephron 8: 440, 1971

    Article  PubMed  CAS  Google Scholar 

  42. Dudrick SJ, MacFadyen BV, Van Buren CT, Ruberg RL, Maynard AT: Parenteral hyperalimentation: Metabolic problems and solutions. Ann Surg 176: 259, 1972

    Article  PubMed  CAS  Google Scholar 

  43. Dudrick SJ, Rhoads JE: Total intravenous feeding. Sci Am 226: 73, 1972

    Article  PubMed  CAS  Google Scholar 

  44. Shils ME: Guidelines for total parenteral nutrition. JAMA 220: 1721, 1972

    Article  PubMed  CAS  Google Scholar 

  45. Abel RM, Beck CH Jr, Abbott WM, Ryan JA Jr, Barnett GO, Fischer JE: Improved survival from acute renal failure after treatment with intravenous essential 1-amino acids and glucose. N Engl J Med 288: 695, 1973

    Article  PubMed  CAS  Google Scholar 

  46. Robinson PJA, Rosen SM: Pyrexial reactions during haemodialysis. Br Med J 1: 528, 1971

    Article  PubMed  CAS  Google Scholar 

  47. Raij L, Shapiro FL, Michael AF: Endotoxemia in febrile reactions during hemodialysis. Kidney Int 4: 57, 1973

    Article  PubMed  CAS  Google Scholar 

  48. Hindman SH, Favero MS, Carson LA, Peterson NJ, Schönberger LB, Solano JT: Pyrogenic reactions during haemodialysis caused by extramural endotoxin. Lancet 2: 732, 1975

    Article  PubMed  CAS  Google Scholar 

  49. Siddiqui JY, Fitz AE, Lawton RL, Kirkenda WM: Causes of death in patients receiving long term hemodialysis. JAMA 212: 1350, 1970

    Article  PubMed  CAS  Google Scholar 

  50. McGowan JE, Barnes MW, Finland M: Bacteremia at the Boston City Hospital. Occurrence and mortality during 12 selected years (1935–1972), with special reference to hospital-acquired cases. J Infect Dis 132: 316, 1975

    Article  PubMed  Google Scholar 

  51. Goodwin NJ, Gastronouvo JJ, Friedman EA: Recurrent septic pulmonary embolization complicating maintenance hemodialysis. Ann Intern Med 71: 29, 1969

    PubMed  CAS  Google Scholar 

  52. Levi J, Robson M, Rosenfeld JB: Septicaemia and pulmonary embolism complicating use of arteriovenous fistula in maintenance haemodialysis. Lancet 2: 288, 1970

    Article  PubMed  CAS  Google Scholar 

  53. Shapiro FL, Messner RP, Smith HT: Satellite hemodialysis. Ann Intern Med 69: 673, 1968

    PubMed  CAS  Google Scholar 

  54. Ribot S, Rothfeld D, Frankel HJ: Infectious endocarditis in maintenance hemodialysis. Am J Med Sci 264: 183, 1972

    PubMed  CAS  Google Scholar 

  55. King LH Jr, Bradley KP, Shires DL Jr, DonohueJP, Glover JL: Bacterial endocarditis in chronic hemodialysis patients; a complication more common than previously suspected. Surgery 69: 554, 1971

    PubMed  Google Scholar 

  56. Ribot S, Gilbert L, Rothfeld EL, Parsonnet V, Jacobs MG: Bacterial endocarditis with pulmonary edema necessitating mitral valve replacement in a hemodialysis-dependent patient. J Thorac Cardiovasc Surg 62: 59, 1971

    PubMed  CAS  Google Scholar 

  57. Goodman JS, Crews HD, Ginn HE, Koenig MG: Bacterial endocarditis as a possible complication of chronic hemodialysis. N Engl J Med 280: 876, 1969

    Article  PubMed  CAS  Google Scholar 

  58. Leonard A, Raij L, Shapiro FL: Bacterial endocarditis in regularly dialyzed patients. Kidney Int 4: 407, 1973

    Article  PubMed  CAS  Google Scholar 

  59. Cross AD, Steigbigel RT: Infective endocarditis and access site infections in patients on hemodialysis. Medicine 55: 453, 1976

    Article  PubMed  CAS  Google Scholar 

  60. Leonard A, Comty CM, Shapiro FL, Raij L: Osteomyelitis in hemodialysis patients. Ann Intern Med 78: 651, 1973

    PubMed  CAS  Google Scholar 

  61. Hochstein HD, Kirkham WR, Young VM: Recovery of more than one organism in septicemias. N Engl J Med 273: 468, 1965

    Article  PubMed  CAS  Google Scholar 

  62. Hermans PE, Washington JA: Polymicrobial bacteremia. Ann Intern Med 73: 387, 1970

    PubMed  CAS  Google Scholar 

  63. Bodey GP, Nies BA, Freireich EJ: Multiple organism septicemia in acute leukemia. Arch Intern Med 116: 266, 1965

    Article  PubMed  CAS  Google Scholar 

  64. Mcintosh CS, Petrie JC, Macleod M: Maintenance of Silastic-Teflon shunts for intermittent haemodialysis. Br Med J 4: 717, 1969

    Article  PubMed  CAS  Google Scholar 

  65. Pendras JP, Smith MP: The Silastic-Teflon arterio-venous cannula. Trans Am Soc Artif Intern Organs 12: 222, 1966

    PubMed  CAS  Google Scholar 

  66. Haimov M: Vascular access for hemodialysis. Surg Gynecol Obstet 141: 619, 1975

    PubMed  CAS  Google Scholar 

  67. Kopp KF, Grossman DF, Frey J: The care and maintenance of the Scribner Teflon-Silastic shunt. Experience how to prevent infection. Proc Eur Dial Transpl Assoc 4: 67, 1967

    Google Scholar 

  68. Brescia MJ, Cimino JE, Appel K, Hurwick BJ: Chronic hemodialysis, using venipuncture and a surgically created arteriovenous fistula. N Engl J Med 275: 1089, 1966

    Article  PubMed  CAS  Google Scholar 

  69. Chinitz J, Yokoyama T, Bower R, Swartz C: Self sealing prosthesis for arteriovenous fistula in man. Trans Am Soc Artif Intern Organs 18: 452, 1972

    Article  PubMed  CAS  Google Scholar 

  70. Zerbino VR, Tice DA, Katz LA, Nidus BD: A six year clinical experience with arteriovenous fistulas and bypasses for hemodialysis. Surgery 76: 1018, 1974

    PubMed  CAS  Google Scholar 

  71. Lytton B, Goffinet JA, May CJ, Weiss RM: Experience with arteriovenous fistula in chronic hemodialysis. J Urol 104: 512, 1967.

    Google Scholar 

  72. Faris TD, Carey TA: Arteriovenous shunts for hemodialysis. Am J Surg 114: 679, 1967

    Article  PubMed  CAS  Google Scholar 

  73. Byrne JP, Stevens LE, Weaver DH, Maxwell JG, Reemtsma K: Advantages of surgical arteriovenous fistulas for hemodialysis. Arch Surg 102: 359, 1971

    Article  Google Scholar 

  74. Ralston AJ, Harlow GR, Jones DM, Davis P: Infections of Scribner and Brescia arteriovenous shunts. Br Med J 3:40, 1971

    Google Scholar 

  75. Haimov M, Baez A, Neff M, Slifkin R: Complications of arteriovenous fistulas for hemodialysis. Arch Surg 110: 708, 1975

    Article  PubMed  CAS  Google Scholar 

  76. VanderWerf BA, Rarrazzi LC, Katzman HA, Schild AF: Three year experience with bovine graft arteriovenous (A-V) fistulas in 100 patients. Trans Am Soc Artif Intern Organs 21: 296, 1975

    Google Scholar 

  77. Merickel JH, Andersen RC, Knutson R, Lipschultz ML, Hitchcock CR: Bovine carotid artery shunts in vascular access surgery. Complications in the chronic hemodialysis patient. Arch Surg 109: 245, 1974

    Article  PubMed  CAS  Google Scholar 

  78. Biggers JA, Remmers AR Jr, Glassford DM, Lindley JD, Sarles HE, Fish JC: Bovine graft fistulas inpatients with vascular access problems receiving hemodialysis. Surgery 140: 690, 1975

    CAS  Google Scholar 

  79. Yokoyama T, Bower R, Chinitz J, Schwartz A, Swartz C: Experience with 100 bovine Arteriografts for maintenance hemodialysis. Trans Am Soc Artif Intern Organs 20: 328, 1974

    Google Scholar 

  80. Kaslow RA, Zellner SR: Infection in patients on maintenance hemodialysis Lancet 2: 117, 1972

    Article  PubMed  CAS  Google Scholar 

  81. Martin AM, Clunie GJA, Tonkin RW, Robson JS: The aetiology and management of shunt infections in patients on intermittent haemodialysis. Proc Eur Dial Transpl Assoc 4: 67, 1967

    Google Scholar 

  82. Dathan JR, Frankel RJ, Goodwin FJ, Marsh FP, Murray M, Thompson JM, Youngs GR: One year experience in a Ministry of Health dialysis centre. Br Med J 2: 102, 1970

    Article  PubMed  CAS  Google Scholar 

  83. Morris A J, Bilinsky RT: Prevention of staphylococcal shunt infections by continuous vancomycin prophylaxis. Am J Med Sci 261: 88, 1971

    Google Scholar 

  84. Pradhan RP, Katz LA, Nidus BD, Matalon R, Eisinger RP: Tuberculosis in dialyzed patients. JAMA 229: 798, 1974

    Article  PubMed  CAS  Google Scholar 

  85. Anderson RJ, Schafer LA, Olin DB, Eickhoff TC: Infectious risk factors in the immunosuppressed host. Am J Med 54: 452, 1973

    Article  Google Scholar 

  86. Myerowitz RL, Medeiros AA, O’Brien TF: Bacterial infection in renal homotrans plant recipients. Am J Med 53: 308, 1972

    Article  PubMed  CAS  Google Scholar 

  87. Eickhoff TC, Olin DB, Anderson RJ, Schafer LA: Current problems and approaches to diagnosis of infection in renal transplant recipients. Transplant Proc 4: 693, 1972

    PubMed  CAS  Google Scholar 

  88. Burgos-Calderon R, Pankey GA, Figueroa JE: Infection in kidney transplantation. Surgery 70: 334, 1971

    PubMed  CAS  Google Scholar 

  89. Rifkind D, Marchioro TL, Schneck SA, Hill RB Jr. Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Am J Med 43: 28, 1967

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1979 Martinus Nijhoff Publishers bv, The Hague

About this chapter

Cite this chapter

Keane, W.F., Raij, L. (1979). Infectious Complications in Maintenance Dialysis Patients. In: Drukker, W., Parsons, F.M., Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9327-3_34

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-9327-3_34

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-247-2227-3

  • Online ISBN: 978-94-009-9327-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics