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Replacement of Renal Function by Dialysis pp 557–570Cite as

Hematologic Problems of Dialysis Patients

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Abstract

As renal excretory function decreases in the patient with chronic progressive renal disease, there is a similar reduction in renal endocrine function, particularly as it concerns the production of either a precursor or the active form of erythropoietin (ESF). Since erythroid function is primarily dependent on ESF stimulation, a hypoproliferative erythroid response occurs leading to a normochromic normocytic anemia. Normally anemia, or more specifically a reduction in tissue oxygenation, is a stimulus to the production of ESF. The diseased kidney cannot respond appropriately to this stimulus, and anemia persists and progresses as functional renal mass decreases. A less important but contributing factor in the anemia of renal failure is the development of mild hemolysis. This generally occurs when the BUN exceeds 100 mg/dl and is thought to be due to retention of some extracorporeal substance that interferes with the red cells’ normal 120 days survival.

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Authors
  1. Joseph W. Eschbach
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of Amsterdam, Netherlands

    William Drukker M.D. (Formerly Reader in Dialysis Emeritus Director) (Formerly Reader in Dialysis Emeritus Director)

  2. Department of Nephrology and Dialysis, St. Lucas Hospital, Amsterdam, The Netherlands

    William Drukker M.D. (Formerly Reader in Dialysis Emeritus Director) (Formerly Reader in Dialysis Emeritus Director)

  3. 75 De Lairessestreet, 1071 NV, Amsterdam, The Netherlands

    William Drukker M.D. (Formerly Reader in Dialysis Emeritus Director) (Formerly Reader in Dialysis Emeritus Director)

  4. Renal Research Unit, Wellcome Wing, The General Infirmary at Leeds, LS1 3EX, Leeds, UK

    Frank M. Parsons B.Sc., M.D., F.R.C.P. Ed. (Consultant Physician Senior Clinical Lecturer in Renal Medicine) (Consultant Physician Senior Clinical Lecturer in Renal Medicine)

  5. University of Leeds, UK

    Frank M. Parsons B.Sc., M.D., F.R.C.P. Ed. (Consultant Physician Senior Clinical Lecturer in Renal Medicine) (Consultant Physician Senior Clinical Lecturer in Renal Medicine)

  6. Health Center, University of Connecticut, 06032, Farmington, CT, USA

    John F. Maher M.D., F.A.C.P. (Professor of Medicine, Director Division of Nephrology) (Professor of Medicine, Director Division of Nephrology)

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© 1979 Martinus Nijhoff Publishers bv, The Hague

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Eschbach, J.W. (1979). Hematologic Problems of Dialysis Patients. In: Drukker, W., Parsons, F.M., Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9327-3_31

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  • DOI: https://doi.org/10.1007/978-94-009-9327-3_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-247-2227-3

  • Online ISBN: 978-94-009-9327-3

  • eBook Packages: Springer Book Archive

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