Skip to main content
SpringerLink
Log in

Glucagon as a Drug

  • Chapter
Glucagon in Gastroenterology

Abstract

The importance of glucagon as a hormone involved in nutrient homeostasis is rapidly growing. Its role in physiology and pathophysiology has recently been the subject of some excellent reviews.1–4 In addition, however, glucagon has a number of pharmacological properties which are not necessarily related to its physiological role. A review of the clinical applications of glucagon as a drug forms the basis of this introductory chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Marks, V. (1972). Glucagon.Clin. Endocrinol. Metab., 3, 829.

    Article  Google Scholar 

  2. Sherwing, R. and Felig, P. (1977). New concepts in glucagon physiology. In P. P. Foa, J. S. Bajaj, and N. L. Foa (eds.) Glucagon: Its Role in Physiology and Clinical Medicine, p.595 (New York: Springer-Verlag).

    Google Scholar 

  3. Unger, R. H., Raskin, P., Srikant, C. B. and Orci, L. (1977). Glucagon and the A cells. In R. O. Greep (ed.) Recent Progress in Hormone Research, vol. 33, p. 477 (New York: Academic Press).

    Google Scholar 

  4. Gerich, J. E. and Lorenzi, M. (1978). The role of the autonomic nervous system and somatostatin in the control of insulin and glucagon secretion. In W. F. Ganongand., L. Martini., (eds.) Frontiers of Neuroendocrinology, vol. 5, p. 265 (New York: Raven Press).

    Google Scholar 

  5. Roth, J., Glick, S. M., Yalow, R. S. and Berson, S. A. (1963). Secretion of human growth hormone: physiologic and experimental modification. Metabolism, 12, 577.

    PubMed  CAS  Google Scholar 

  6. Danforth, E. and Rosenfeld, P. S. (1970). Effect of intravenous glucagon on circulating levels of growth hormone and 17-hydroxicorticosteroids. J. Clin. Endocrinol. Metab., 30, 117.

    Article  PubMed  CAS  Google Scholar 

  7. Milner, R. D. G. and Wright, A. D. (1966). Blood glucose, plasma insulin and growth hormone response to hyperglycaemia in the newborn. Clin. Sci., 31, 309.

    PubMed  CAS  Google Scholar 

  8. Mitchell, M. L., Byrne, M. J. and Sawin, G. T. (1969). Growth hormone release by glucagon. Lancet, i, 289.

    Article  CAS  Google Scholar 

  9. Podolsky, S. and Sivaprassad, R. (1972). Assessment of growth hormone reserve: comparison of intravenous arginine and subcutaneous glucagon stimulation tests. J. Clin. Endocrinol. Metab., 35, 580.

    Article  PubMed  CAS  Google Scholar 

  10. Mitchell, M. L., Byrne, M. J., Sanchez, Y. and Sawin, G. T. (1970). Detection of growth hormone deficiency.. V.Engl. J. Med., 282, 539.

    Article  CAS  Google Scholar 

  11. Gain, J. P., Williams, G. H. and Dluhy, R. G. (1970). Glucagon stimulation of human growth hormone. J. Clin. Endocrinol. Metab., 31, 222.

    Article  Google Scholar 

  12. Mitchell, M. L., Suvunrungsi, P. and Sawin, G. (1971). Effect of propranolol on the response of serum growth hormone to glucagon. J. Clin. Endocrinol. Metab.; 32, 470.

    Article  PubMed  CAS  Google Scholar 

  13. Wieland, R. G., Hallberg, M. C. and Zorn, E. M. (1973). Growth hormone response to intramuscular glucagon. J. Clin. Endocrinol. Metab., 37, 329.

    Article  PubMed  CAS  Google Scholar 

  14. Lefebvre, P. J., Cession-Fossion, A., and Luyckv, A. S. (1966). Glucagon test for phaeochromocytoma. Lancet, ii, 1366.

    Google Scholar 

  15. Joasoo, A. and Freeman, A. (1967). Tyramine and glucagon in phaeo chromocytoma. Lancet, ii, 726.

    Article  Google Scholar 

  16. Lawrence, A. M. (1967). Glucagon provocative test for phaeochromo cytoma. Ann. Intern. Med., 66, 1091.

    PubMed  CAS  Google Scholar 

  17. Sheps, S. G. and Mäher, F. T. (1968). Histamine and glucagon test in diagnosis of phaeochromocytoma. J. Am. Med. Assoc., 205, 895.

    Article  CAS  Google Scholar 

  18. Brunner, H., Grabner, G., Michalek, G.P. and Paumgartner, G. (1968). Die Beurteilung der Leberfunktion mit Hilfe des Glukagon-Tests. Wien. £ Inn. Med., 49, 409.

    CAS  Google Scholar 

  19. Grabner, G. and Neumayr, A. (1964). Probleme über Wechselbeziehungen zwischen Leberdurchblutung und Stoffwechsel. Wien. Inn. Med., 45,523.

    CAS  Google Scholar 

  20. Hardman, J. G., Davies, J. W. and Sutherland, E. W. (1969). Effects of some hormonal and other factors on the excretion of guanosine 3’, 5’- monophosphate and adenosine 3’, 5’-monophosphate in rat urine. J. Biol. Chem., 244, 6354.

    PubMed  CAS  Google Scholar 

  21. Broadus, A. E., Kaminsky, N. I. and Northcutt, R. G. (1970). Effects of glucagon on adenosine 3’, 5’-monophosphate in human plasma and urine. J.Clin. Invest., 49, 2237.

    Article  PubMed  CAS  Google Scholar 

  22. Strange, R. G. and Mjos, O. D. (1975). The sources of plasma cyclic AMP: studies in the rat using isoprenaline, nicotinic acid, and glucagon. Eur. J. Clin. Invest., 5, 147.

    PubMed  CAS  Google Scholar 

  23. Davies, T. F, Prudhoe, K. and Douglas, A. P. (1976). Plasma cyclic adenosine 3’, 5’-monophosphate response to glucagon in patients with liver disease. Br. Med. J., 1, 931.

    Article  PubMed  CAS  Google Scholar 

  24. Quirarte, G., Woodward, E.R. and Dragstedt, L. R. (1966). Glucagon and inhibition ol gastric secretion. Arch. Surg., 93, 475. 25.

    Google Scholar 

  25. Lin, T. M., Evans, D.G. and Spray, G.F. (1973). Mechanism studies of gastric inhibition by glucagon. Failure of KG1 and adrenergic blocking agents to prevent its action. Arch. Int. Pharmacodyn., 202, 314.

    PubMed  CAS  Google Scholar 

  26. Hess, A. F. (1913). The gastric secretion of infants at birth. Ann. J. Dis. Child., 6, 264.

    Google Scholar 

  27. Rogers, I. M., Davidson, D. G., Lawrence, J., Ardill, J. and Buchanan, K. D. (1974). Neonatal secretion of gastrin and glucagon. Arch. Dis. Mid., 49, 796.

    CAS  Google Scholar 

  28. Konturek, S. J., Biernat, J., Kwiecen, N. and Olesky, J. (1975). Effect of glucagon on meal-induced gastric secretion in man. Gastroenterology, 68, 448. 1

    Google Scholar 

  29. Gomez Pan, A., Reed, J. D., Albinus, M., Shaw, B., Hall, R., Besser, G. M., Gov, D. H., Kastin, A. J. and Schally, A. V. (1975). Direct inhibition of gastric acid and pepsin secretion by growth hormone release-inhibiting hormone in cats. Lancet, i, 888.

    Article  Google Scholar 

  30. Albinus, M., Blair, E. L., Case, R. M., Coy, D. H., Gomez Pan, A., Hirst, B. H., Reed, J. D., Schally, A. V., Shaw, B., Smith, P. A. and Smy, J. R. (1977). Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas. J. Physiol, 269, 77.

    PubMed  CAS  Google Scholar 

  31. Patton, G. S., Dobbs, R., Orci, L., Vale, W. and Unger, R. H. (1976). Stimulation of pancreatic immunoreactive somatostatin (IRS) release by glucagon. Metabolism, 25, suppl. 1, 1499.

    Article  PubMed  CAS  Google Scholar 

  32. Parmley, W. M., Glick, G., and Sonnenblick, E. H. (1968). Cardiovascular eifects of glucagon in man. N. Engl. J. Med., 279, 12.

    Article  PubMed  CAS  Google Scholar 

  33. Steiner, C., Wit, A. L. and Damato, A. N. (1976). Eifects of glucagon on atrioventricular conduction and ventricular automaticity in dogs. Circ. Res., 24, 167.

    Google Scholar 

  34. Fazah, A. and Tuttle, R. (1960). Studies on the pharmacology of glucagon. J. Pharmacol. Exp. Ther., 129, 49.

    Google Scholar 

  35. Regan, T. J., Lehan, P. H., Henneman, D. H., Behar, A. and Hellems, H. K. (1964). Myocardial metabolic and contractile response to glucagon and epinephrine. J. Lab. Clin. Med., 63, 638.

    PubMed  CAS  Google Scholar 

  36. Whitehouse, F. W. and James, T. N. (1966). Chronotropic action of glucagon on the sinus node.Proc. Soc. Exp. Biol. Med., 122, 823.

    PubMed  CAS  Google Scholar 

  37. Brogan, E., Kozonis, M. C. and Overy, D. C. (1969). Glucagon therapy in heart failure. Lancet, i, 482.

    Article  Google Scholar 

  38. Eddy, J. D., O’Brien, E. T. and Singh, S. P. (1969). Glucagon and haemodynamics of acute myocardial infarction. Br. Med. J., 4, 663.

    Article  PubMed  CAS  Google Scholar 

  39. Greenberg, B. H., Tsakiris, A. G. and Moffitt, E. A. (1970). The haemodynamic and metabolic effects of glucagon in patients with chronic valvular heart disease. Mayo Clin. Proc., 45, 132.

    PubMed  CAS  Google Scholar 

  40. Murtagh, J. G., Binnion, P. F. and Lai, S. (1970). Haemodynamic eifects of glucagon. Br. Heart J., 32, 307.

    Article  PubMed  CAS  Google Scholar 

  41. Nord, H. J., Fontanes, A. L. and Williams, J. F. (1970). Treatment of congestive heart failure with glucagon.Ann. Intern Med., 72, 649.

    PubMed  CAS  Google Scholar 

  42. Wilcken, D. E. L. and Lvoff, R. (1970). Glucagon in resistant heart failure and cardiogenic shock. Lancet, i, 1315.

    Google Scholar 

  43. Fajans, S. S. (1976). Fasting hypoglycaemia in adults. N. Engl. J. Med., 294, 766.

    Google Scholar 

  44. Marks, V. (1971). Diagnosis of insulinoma. Gut, 12, 835.

    Article  PubMed  CAS  Google Scholar 

  45. Khurana, R. C. and Nolan, S. (1971). Insulin and glucose patterns in control subjects and in proven insulinoma. Am. J. Med. Sci., 262, 115.

    Article  PubMed  CAS  Google Scholar 

  46. Marks, V. and Alberti, K. G. (1976). Selected tests of carbohydrate metabolism. Clin. Endocrinol. Metab., 5, 805.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. Gomez-Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Blesa Malpica
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. D. Rodriguez Arnao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Oriol Bosch
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

J. Picazo M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1979 MTP Press Limited

About this chapter

Cite this chapter

Gomez-Pan, A., Malpica, G.B., Arnao, M.D.R., Bosch, A.O. (1979). Glucagon as a Drug. In: Picazo, J. (eds) Glucagon in Gastroenterology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9212-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-9212-2_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-9214-6

  • Online ISBN: 978-94-009-9212-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation