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Hepatotrophic Effects of Insulin and Glucagon and their Potential Role in the Treatment of Hepatic Failure

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Glucagon in Gastroenterology

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Abstract

Disorders of the liver, particularly alcohol-related cirrhosis, are a major cause of death throughout the world and the incidence is rising.1 Currently available therapies have done little to improve the overall survival of patients with fulminant hepatitis due to viruses, alcohol or other toxins.2–4 In addition, merely treating the complications of chronic liver disease, such as portacaval shunt operations for bleeding oesophageal varices, does not appear to increase survival since the majority of these patients subsequently die of hepatic failure.5 6 Unless a significant impact is made in preventing liver disease, new forms of therapy are necessary to increase survival of patients with acute and chronic liver failure.

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References

  1. Massé, L., Juillan, J. M. and Chisloup, A. (1976). Trends in mortality from cirrhosis of the liver. World Health Statistics Report, 29, 40.

    Google Scholar 

  2. Gregory, P. B., Knauer, C. M., Kempson, R. L. et al. (1976). Steroid therapy in severe viral hepatitis. Double-blind randomized trial of methyl-pred-nisolone versus placebo. N. Engl. J. Med., 294, 681.

    Article  PubMed  CAS  Google Scholar 

  3. Gonn, H. O. (1978). Steroid treatment of alcoholic hepatitis. Gastroenterology, 74, 319.

    Google Scholar 

  4. Sherlock, S. (1975). Acute (fulminant) hepatic failure. In S. Sherlock, (ed.). Diseases of the Liver and Biliary System, 5th ed., pp. 107–121. (Oxford: Blackwell Scientific Publications).

    Google Scholar 

  5. Conn, H. O., Lindenmuth, W. W., May, C. J. et al. (1972). Prophylactics portacaval anastomosis. Medicine, 51, 27.

    Article  PubMed  CAS  Google Scholar 

  6. Resnick, R. H., Iber, F. L., Ishihara, A. M. et al.(1974). Controlled study of the therapeutic portacaval shunt. Gastroenterology, 67, 843.

    PubMed  CAS  Google Scholar 

  7. Starzl, T. E., Marchioro, T. L., Rowlands, D. T. Jr.et al.(1964). Immuno suppression after experimental and clinical homotransplantation of the liver. Ann. Surg., 160, 411.

    Article  PubMed  CAS  Google Scholar 

  8. Marchioro, T. L., Porter, K. A., Dickinson, T. C. et al. (1965). Physiologic requirements for auxiliary liver homotransplanation. Surg. Gynec. Obstet., 121, 17.

    PubMed  CAS  Google Scholar 

  9. Marchioro, T. L., Porter, K. A., Brown, B. I. et al. (1967). Effect of partial portacaval transposition on the canine liver. Surgery, 61, 723.

    PubMed  CAS  Google Scholar 

  10. Fisher, B., Szuch, P., Levine, M. et al. (1971). Portal blood factor as the humoral agent in liver regeneration. Science, 171, 575.

    Article  PubMed  CAS  Google Scholar 

  11. Fisher, B., Szuch, P. and Fisher, E. R. (1971). Evaluation of a humoral factor in liver regeneration utilizing liver transplants. Cancer Res., 31, 322.

    PubMed  CAS  Google Scholar 

  12. Lee, S., Chandler, J. G., Williams, R. et al. (1971). Trophic factor in portal blood required for liver regeneration. Gastroenterology, 60, 688.

    Google Scholar 

  13. Chandler, J. G., Lee, S., Krubel, R. et al. (1971). Inter-liver competition and portal blood in regeneration of auxiliary liver transplants. Surg. Forum, 22, 341.

    PubMed  CAS  Google Scholar 

  14. Orloff, M. J., Lee, S., Chandler, J. G. et al. (1972). Humoral regulation of liver regeneration by a hepatotrophic portal blood factor. Gastroenterology, 62, 791.

    Google Scholar 

  15. Max, M. H., Price, J. B., Takeshige, K. et al. (1972). Role of factors of portal origin in modifying hepatic regeneration. J. Surg. Res., 12, 120.

    Article  PubMed  CAS  Google Scholar 

  16. Lee, S., Duguay, L. R. and Orloff, M. J. (1972). Pancreas extract and liver regeneration. Surg. Forum, 27, 358.

    Google Scholar 

  17. Price, J. B. Jr., Takeshige, K., Max, M. H. et al. (1972). Glucagon as the portal factor modifying hepatic regeneration. Surgery, 72, 74.

    PubMed  Google Scholar 

  18. Sgro, J. C, Charters, A. C., Chandler, J. G. et al. (1973). Site of origin of the hepatotrophic portal blood factor involved in liver regeneration. Surg. Forum, 24, 377.

    PubMed  CAS  Google Scholar 

  19. Whittemore, A. D., Kasuya, M., Fodor, P. B. et al. (1973). Hepatic regeneration in the rat without portal organs. Surg. Forum, 24, 384.

    PubMed  CAS  Google Scholar 

  20. Starzl, T. E., Francavilla, A., Halgrimson, C. G. et al. (1973). Origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg. Gynecol. Obstet., 137, 179.

    PubMed  CAS  Google Scholar 

  21. Ozawa, K., Yamaoka, Y., Nanbu, H. et al. (1974). Insulin as the primary factor governing changes in mitochondrial metabolism leading to liver regeneration and atrophy. Am. J. Surg., 127, 669.

    Article  PubMed  CAS  Google Scholar 

  22. Whittemore, A. D., Kasuya, M., Voorhees, A. B. Jr.et al. (1975). Hepatic regeneration in the absence of portal viscera. Surgery, 77,419.

    PubMed  CAS  Google Scholar 

  23. Bucher, N. L. R. and Swaffield, M. N. (1975). Regulation of hepatic regeneration in rats by synergistic action of insulin and glucagon. Proc. Natl. Acad. Sci. USA, 72, 1157.

    Article  PubMed  CAS  Google Scholar 

  24. Starzl, T. E., Porter, K. A., Kashiwagi, N. et al. (1975). Effect of diabetes mellitus on portal blood hepatotrophic factors in dogs. Surg. Gynecol. Obstet., 140, 549.

    PubMed  CAS  Google Scholar 

  25. Bucher, N. L. R. and Swaffield, M. N. (1975). Synergistic action of glucagon and insulin in regulation of hepatic regeneration. Adv. Enzyme Regul.., 13, 281.

    PubMed  CAS  Google Scholar 

  26. Starzl, T. E., Porter, K. A., Kashiwagi, N. et al. (1975). Portal hepatotrophic factors, diabetes mellitus and acute atrophy, hypertrophy and regeneration. Surg. Gynecol. Obstet., 141, 843.

    PubMed  CAS  Google Scholar 

  27. Starzl, T. E., Porter, K. A., and Putnam, C. W. (1975). Intraportal insulin protects from the liver injury of portacaval shunt in dogs. Lancet, ii, 1241.

    Article  Google Scholar 

  28. Bucher, N. L. R. (1976). Insulin, glucagon, and the liver. Adv. Enzyme Regul, 15, 221.

    Article  PubMed  CAS  Google Scholar 

  29. Chandler, J. G. (1976). Hepatotrophic activity in nonpancreatic, non-duodenal portal blood. Surg. Forum, 27, 360.

    PubMed  CAS  Google Scholar 

  30. Sakai, A., Pfeffermann, R., Taha, M. et al. (1976). Origin of regeneration factor. Surg. Forum, 27, 45.

    PubMed  CAS  Google Scholar 

  31. Whittemore, A. D., Voorhees, A. B. Jr. and Price, J. B. Jr. (1976). Hepatic blood How and pancreatic hormones as modifiers of hepatic regeneration. Surg. Forum, 27, 363.

    PubMed  CAS  Google Scholar 

  32. Starzl, T. E., Watanabe, K., Porter, K. A. et al. (1976). Effects of insulin, glucagon, and insulin/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet, i, 821.

    Article  Google Scholar 

  33. Rosenkranz, E., Duguay, L. R. and Orloff, M. J. (1976). Effect of liver regeneration on pancreatic hormone levels in blood. Gastroenterology, 70, 991.

    Google Scholar 

  34. Price, J. B. (1976). Insulin and glucagon as modifiers of DNA synthesis in the regenerating rat liver. Metabolism, 25, (suppl. 1), 1427.

    Article  PubMed  CAS  Google Scholar 

  35. Bucher, N. L. R. and Weir, G. C. (1976). Insulin, glucagon, liver regeneration, and DNA synthesis. Metabolism, 25, (suppl. 1), 1423.

    Article  PubMed  CAS  Google Scholar 

  36. Starzl, T. E., Porter, K. A. and Putnam, C. W. (1976). Insulin, glucagon and the control of hepatic structure, function, and capacity for regeneration. Metabolism, 25, (suppl. 1), 1429.

    Article  PubMed  CAS  Google Scholar 

  37. Farivar, M., Wands, J. R., Isselbacher, K. J. et al. (1976). Effect of insulin and glucagon on fulminant murine hepatitis. N. Engl. J. Med., 295, 1517.

    Article  PubMed  CAS  Google Scholar 

  38. Duguay, L. R., Skivolocki, W. P., Lee, S. et al. (1977). Regulation of liver regeneration by pancreatic hormones. Gastroenterology, 72, 1053.

    Google Scholar 

  39. Yamada, T., Yamamoto, M., Ozawa, K. et al. (1977). Insulin requirements for hepatic regeneration following hepatectomy. Ann. Surg., 185, 35.

    Article  PubMed  CAS  Google Scholar 

  40. Popper, H. (1974). Implications of portal hepatotrophic factors in hepatology. Gastroenterology, 66, 1227.

    PubMed  CAS  Google Scholar 

  41. Editorial (1975). Insulin and the liver. Lancet, ii, 1245.

    Google Scholar 

  42. Sherlock, S. (1976). Portal venous ‘goodies’ and fulminant viral hepatitis. N. Engl. J. Med., 295, 1535.

    Article  PubMed  CAS  Google Scholar 

  43. Rous, P. and Larimore, L. D. (1920). Relation of the portal blood to liver aintenance. A demonstration of liver atrophy conditional on compensation. J. Exp. Med., 31, 609.

    Article  PubMed  CAS  Google Scholar 

  44. Mann, F. C., Fishback, F. C., Gay, J. G. et al.(1931). Experimental pathology of the liver. Studies III, IV, and V. Arch. Pathol., 12, 787.

    Google Scholar 

  45. Mann, F. C. (1940). The portal circulation and restoration of the liver after partial removal. Surgery, 8, 225.

    Google Scholar 

  46. Stephenson, G. W. (1932). Experimental pathology of the liver. IX. Restoration of the liver after partial hepatectomy and partial ligation of the portal vein. Arch. Pathol., 14, 484.

    Google Scholar 

  47. Child, C. G. Ill, Barr, D., Holswade, G. R. et al. (1953). Liver regeneration following portacaval transposition in dogs. Ann. Surg., 138, 600.

    Article  PubMed  Google Scholar 

  48. Fisher, B., Russ, C., Updegraff, H. et al. (1954). Effect of increased hepatic blood flow upon liver regeneration. Arch. Surg., 69, 263.

    CAS  Google Scholar 

  49. Skivolocki, W. P. and Orloff, M. J. (1978). Stimulation of liverregeneration by pancreatic hepatotrophic factors other than insulin and glucagon. Gastroenterology, 74, 1097.

    Google Scholar 

  50. Bucher, N. L. R. and Swaflleld, M. N. (1973). Regeneration of liver in rats in the absence of portal splanchnic organs and a portal blood supply. Cancer Res., 33, 3189.

    PubMed  CAS  Google Scholar 

  51. Amherdt, M., Harris, V., Renold, A. E. et al. (1974). Hepatic autophagy in uncontrolled experimental diabetes and its relationships to insulin and glucagon. J. Clin. Invest., 54, 188.

    Article  PubMed  CAS  Google Scholar 

  52. Deter, R. L. (1975). Analog modeling of glucagon-induced autophagy in rat liver. I - Conceptual and mathematical model of telolysosome-auto- phagosome-autolysosome interaction. Exp. Cell Res., 94, 122.

    Article  PubMed  CAS  Google Scholar 

  53. Younger, L. R., King, J. and Steiner, D. F. (1966). Hepatic proliferative response to insulin in severe alloxan diabetes. Cancer Res., 26, 1408.

    PubMed  CAS  Google Scholar 

  54. Reaven, E. P., Peterson, D. T. and Reaven, G. M. (1973). Effect of experimental diabetes mellitus and insulin replacement on hepatic ul- trastructure and protein synthesis. J. Clin. Invest., 52, 248.

    Article  PubMed  CAS  Google Scholar 

  55. Leffert, H. L., Koch, K. S. and Rubalcava, B. (1976). Present paradoxes in the environmental control of hepatic proliferation. Cancer Res., 36, 4250.

    PubMed  CAS  Google Scholar 

  56. Holley, R. W. (1975). Control of growth of mammalian cells in cell culture. Nature, 258, 487.

    Article  PubMed  CAS  Google Scholar 

  57. Richman, R. A., Claus, T. H., Pilkis, S. J. et al.(1976). Hormonal stimuli tion of DNA synthesis in primary cultures of adult rat hepatocytes. Proc. Natl. Acad. Sci. USA, 73, 3589.

    Article  PubMed  CAS  Google Scholar 

  58. Wands, J. R., Storer, R., Patel, U. et al. (1977). Pancreatic hormonal influence on D-galactosamine induced acute liver cell injury. Gastroenterology, 73, 1253.

    Google Scholar 

  59. Tolman, K. G. and Gray, P. (1978). Protective effect of insulin and glucagon in salicylate hepatotoxicity. Clin. Res., 26, 114A.

    Google Scholar 

  60. Lindberg, B., Haljamäe, H., Jonsson, O. et al. (1978). Effect of glucagon and blood transfusion on liver metabolism in hemorrhagic shock. Ann. Surg., 187, 103.

    Article  PubMed  CAS  Google Scholar 

  61. Krarup, N. and Larsen, J. A. (1974). The effect of glucagon on hepatosplanchnic hemodynamics, functional capacity, and metabolism of the liver in cats. Acta Physiol. Scand., 91, 42.

    Article  PubMed  CAS  Google Scholar 

  62. Creutzfeldt, W., Frerichs, H. and Sickinger, K. (1970). Liver diseases and diabetes mellitus. In H. Popper and F. Shaffner, (eds.). Progress in Liver Diseases, pp. 371–407. (New York: Grune and Stratton).

    Google Scholar 

  63. Thompson, E. N., Williams, R. and Sherlock, S. (1964). Liver function in extrahepatic portal hypertension. Lancet, ii, 1352.

    Article  Google Scholar 

  64. Mallinson, C. N., Bloom, S. R., Warin, A. P. et al.(1974). A glucagonoma syndrome. Lancet, ii, 1.

    Article  Google Scholar 

  65. Boden, G., Owen, O. E., Rezvani, I. et al. (1977). An islet cell carcinoma containing glucagon and insulin. Chronic glucagon excess and glucose homeostasis. Diabetes, 26, 128.

    Article  PubMed  CAS  Google Scholar 

  66. Munro, H. N., Fernstrom, J. D. and Wurtman, R.J. (1976). Insulin, plasma aminoacid imbalance, and hepatic coma. Lancet, i, 722.

    Google Scholar 

  67. Soeters, P. B. and Fischer, J. E. (1976). Insulin, glucagon, amino acid imbalance, and hepatic encephalopathy. Lancet , ii, 880.

    Article  Google Scholar 

  68. Soeters, P. B., Weir, G., Ebeid, A. M. et al. (1977). Insulin, glucagon, portal systemic shunting, and hepatic failure in the dog. J. Surg. Res., 23, 183.

    Article  PubMed  CAS  Google Scholar 

  69. Sherwin, R., Joshi, P., Hendler, R. et al. (1974). Hyperglucagonaemia in Laennec’s cirrhosis. The role of portal-systemic shunting..V. Engl. J. Med., 290, 239.

    Article  CAS  Google Scholar 

  70. Shurberg, J. L., Resnick, R. H., Kofi, R. S. et al. (1977). Serum lipids,insulin, and glucagon after portacaval shunt in cirrhosis. Gastroenterology, 72, 301.

    PubMed  CAS  Google Scholar 

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  1. N. A. Volpicelli
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J. Picazo M.D.

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Volpicelli, N.A. (1979). Hepatotrophic Effects of Insulin and Glucagon and their Potential Role in the Treatment of Hepatic Failure. In: Picazo, J. (eds) Glucagon in Gastroenterology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9212-2_10

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  • DOI: https://doi.org/10.1007/978-94-009-9212-2_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-9214-6

  • Online ISBN: 978-94-009-9212-2

  • eBook Packages: Springer Book Archive

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