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Nucleophilicity of DNA. Relation to Chemical Carcinogenesis.

  • Bernard Pullman
  • Alberte Pullman
Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 13)

Abstract

It seems well established today that the active forms of a large number of carcinogenic substances (the so-called proximate or ultimate carcinogens) are electrophilic agents: positive ions or uncharged molecules with reactive centers at their electron deficient atoms (see e.g. 1,2). This is true both for carcinogens considered as being active per se (a number of relatively simple alkylating agents) and those which necessitate a metabolic activation (aromatic hydrocarbons, aromatic amines, aflatoxin B1 etc.) (Fig. 1).

Keywords

eLectrostatic moLecuLar potentiaLs Nucleic Acid Research Chemical Carcinogenesis Exchange repuLsion dioL Epoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© D. Reidel Publishing Company 1980

Authors and Affiliations

  • Bernard Pullman
    • 1
  • Alberte Pullman
    • 1
  1. 1.Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théoriqueassocié au C.N.R.S.ParisFrance

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