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The Induction, Expression and Modulation of Radiation Induced Oncogenesis in vitro in Diploid Human and Rodent Cells

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Carcinogenesis: Fundamental Mechanisms and Environmental Effects

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 13))

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Abstract

Techniques developed to identify radiation induced oncogenesis in cultured rodent cells have enabled the qualitative and quantitative assessment of the oncogenic potential of radiation and the identification of factors which modulate these events. Because of the revelance to estimating human cancer risk development of analogous systems using diploid human cells is of great importance. Recently we have shown for the first time that human diploid cells can be transformed in vitro by X irradiation into malignant cells which give rise to tumors in animals. The frequency of human cell transformation is lower compared to that observed in animal cells given the same dose.

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Author information

Authors and Affiliations

  1. Radiological Research Laboratory, Department of Radiology, Department of Pathology, Cancer Center/Institute of Cancer Research, Columbia University, College of Physicians and Surgeons, New York, NY, 10032, USA

    Carmia Borek

Authors
  1. Carmia Borek
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université Pierre et Marie Curie (Paris VI), Paris, France

    Bernard Pullman

  2. The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Cancer Institute, Bethesda, Maryland, USA

    Harry Gelboin

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© 1980 D. Reidel Publishing Company

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Borek, C. (1980). The Induction, Expression and Modulation of Radiation Induced Oncogenesis in vitro in Diploid Human and Rodent Cells. In: Pullman, B., Ts’o, P.O.P., Gelboin, H. (eds) Carcinogenesis: Fundamental Mechanisms and Environmental Effects. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9104-0_43

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  • DOI: https://doi.org/10.1007/978-94-009-9104-0_43

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-9106-4

  • Online ISBN: 978-94-009-9104-0

  • eBook Packages: Springer Book Archive

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