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Modulation of Repair of DNA Damages Induced by Nitrosamines

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Carcinogenesis: Fundamental Mechanisms and Environmental Effects

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 13))

Abstract

The persistence of various DMA alkylation products (7-methyl-guanine, 3-methyladenine and 06-mcthylguanine) was examined in the liver of rats following chronic administration of low doses of dinethylnitrosamine. The treatment resulted in an increased removal of 0 6-methylguanine due to an inducible DNA repair process. These observations in rat liver arc discussed with reference to a similar inducible repair process observed in E. coli exposed to low doses of the alkylating agent, N-methyl-N’-nitro-N-nitrosoguanidine.

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Author information

Authors and Affiliations

  1. Division of Chemical and Biological Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cédex 2, France

    Ruggero Montesano

  2. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, Great Britain

    Geoffrey P. Margison

Authors
  1. Ruggero Montesano
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  2. Geoffrey P. Margison
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université Pierre et Marie Curie (Paris VI), Paris, France

    Bernard Pullman

  2. The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Cancer Institute, Bethesda, Maryland, USA

    Harry Gelboin

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© 1980 D. Reidel Publishing Company

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Montesano, R., Margison, G.P. (1980). Modulation of Repair of DNA Damages Induced by Nitrosamines. In: Pullman, B., Ts’o, P.O.P., Gelboin, H. (eds) Carcinogenesis: Fundamental Mechanisms and Environmental Effects. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9104-0_36

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  • DOI: https://doi.org/10.1007/978-94-009-9104-0_36

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-9106-4

  • Online ISBN: 978-94-009-9104-0

  • eBook Packages: Springer Book Archive

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