Advertisement

The Effect of 12-0-Tetradecanoyl-Phorbol-13-Acetate (TPA) on Cell Transformation by Simian Virus 40 Mutants

  • R. Monier
  • L. Daya-Grosjean
  • A. Sarasin
Conference paper
Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 13)

Abstract

The effect of TPA on the transformation of Swiss 3T3 cells to anchorage-independent growth by the tsA 58 mutant of SV40 has been investigated. At the restrictive temperature of 39°C, the combined action of the tsA 58 mutant and of TPA allows the formation of soft-agar colonies from Swiss 3T3 cells. No colonies were observed when either one or the other agent was omitted. Antipaín had no inhibitory effect on this phenomenon. TPA also stimulates the anchorage-independent growth of cells previously transformed by either the tsA 58 mutant or the dl 2112 mutant.

Keywords

Sister Chromatid Exchange Wild Type Virus Restrictive Temperature Macroscopic Coloni SV40 Mutant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Crawford, L.V., Cole, C.N., Smith, A.E., Paucha, E., Tegtmeyer, P., RundelL, K., and Berg, P.: 1978, Proc.NatI.Acad.Sci., USA 75, pp. 117–121.CrossRefGoogle Scholar
  2. Daya-Grosjean, L., and Monier, R.: 1978, J.Virol. 27, pp. 307–312.Google Scholar
  3. Feunteun, J., Kress, M., Gardes, M., and Monier, R.: 1978, Proc.Natl Acad.Sci., USA 75, pp. 4455–4459.CrossRefGoogle Scholar
  4. Fisher, P.B., Weinstein, I.B., Eisenberg, D., and Ginsberg, H.S.: 1978, Proc.Natl.Acad.Sci., USA 75, pp. 2311–2314.CrossRefGoogle Scholar
  5. Fisher, P.B., Dorsch-Hasler, K., Weinstein, I.B., and Ginsberg, H.S. 1979, Nature 281, pp. 591–594.CrossRefGoogle Scholar
  6. Fisher, P.B., Bozzone, J.H., and Weinstein, I.B.: 1979, Cell 18, pp. 695–705.CrossRefGoogle Scholar
  7. Fluck, M.M., and Benjamin, T.: 1979, Virology 96, pp. 205–228.CrossRefGoogle Scholar
  8. Hozumi, K., Ogawa, M., Sugimura, T., Takeuchi, T., and Umezawa, H.: 1972, Cancer Res. 32, pp. 1725–1728.Google Scholar
  9. Kennedy, A.R., Mondal, S., Heidelberger, C., and Little, J.B.: 1978, Cancer Res. 38, pp. 439–443.Google Scholar
  10. Kinsella, A., and Radman, M.: 1978, Proc.Natl.Acad.Sci., USA 75, pp. 6149–6153.CrossRefGoogle Scholar
  11. Lasne, C., Gentil, A., and Chouroulinkov, I.: 1974, Nature 247, pp. 490–491.CrossRefGoogle Scholar
  12. Lewis, A.M., Jr, and Martin, R.G.: 1979, Proc.Natl.Acad.Sci., USA 76 pp. 4299–4302.CrossRefGoogle Scholar
  13. MacPherson, I., and Montagnier, L.: 1964, Virology 23, pp. 291–294.CrossRefGoogle Scholar
  14. May, E., Kress, M., and May, P.: 1978, Nucl.Acids Res. 5, pp. 3083–3100.CrossRefGoogle Scholar
  15. Mondal, S., and Heidelberger, C.: 1976, Nature 260, pp. 710–711.CrossRefGoogle Scholar
  16. Honda, S., Branrow, D.W., and Heidelberger, C.: 1976, Cancer Res. 36, pp. 2254–2260.Google Scholar
  17. Nagawa, H., and Little, J.B.: 1979, Proc.Natl.Acad.Sci., USA 76, pp. 1943–1947.CrossRefGoogle Scholar
  18. Seif, R., and Martin, R.G.: 1979, J.Virol. 32, pp. 979–988.Google Scholar
  19. Sivak, A., and van Duuren, B.L.: 1967, Science 157, pp. 1443–1444.CrossRefGoogle Scholar
  20. Sleigh, M.J., Topp, W.C., Hanich, R., and Sambrook, J.F.: 1978, Cell 14, pp. 79–88.CrossRefGoogle Scholar
  21. Suarez, H.G., Cassingena, R., Estrade, S., Wicker, R., Lavialle, C., and Lazar, P.: 1974, Archgesamte Virusforsch. 46, pp. 93–104.CrossRefGoogle Scholar
  22. Tegtmeyer, P.: 1972, J.Virol. 10, 591 - 598.Google Scholar
  23. Troll, W., Klassen, A., and Janoff, A.: 1970, Science 169, pp. 1211–1213.CrossRefGoogle Scholar
  24. Volckaert, G., Feunteun, J., Crawford, L.V., Berg, P., and Fiers, W.: 1979, J.Virol. 30, pp. 674–682.Google Scholar

Copyright information

© D. Reidel Publishing Company 1980

Authors and Affiliations

  • R. Monier
    • 1
  • L. Daya-Grosjean
    • 1
  • A. Sarasin
    • 1
  1. 1.Institut de recherches scientifiques sur le cancer (Villejuif)France

Personalised recommendations