Effect of Bleomycin Scheduling on Lung Metastases of 3LL and a Subline of Different Metastatic Potential
In the past ten years several reports have shown the heterogeneous nature of both the human and experimental neoplasm. In fact, many authors demonstrated the existence of distinct cell subpopulations in the tumours differing in various characteristics like number of chromosomes, DNA content, antigenic properties, metastatic potential (Fidler, 1978). Moreover, it has been pointed out that the employment of such tumour sublines selected within the same tumour represents a useful tool for experimental chemotherapy studies (Lotan et al., 1979).
KeywordsFractionation Dition Bleomycin Adriamycin
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