Effect of Bleomycin Scheduling on Lung Metastases of 3LL and a Subline of Different Metastatic Potential
In the past ten years several reports have shown the heterogeneous nature of both the human and experimental neoplasm. In fact, many authors demonstrated the existence of distinct cell subpopulations in the tumours differing in various characteristics like number of chromosomes, DNA content, antigenic properties, metastatic potential (Fidler, 1978). Moreover, it has been pointed out that the employment of such tumour sublines selected within the same tumour represents a useful tool for experimental chemotherapy studies (Lotan et al., 1979).
KeywordsLewis Lung Carcinoma Tumour Line Tumour Implantation Original Line Lewis Lung Carcinoma Cell
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- Fidler,I.J.,1978. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res., 38: 2651–2660Google Scholar
- Greco,C.,Caiabresi,F.,Caputo,M., Corsi,A.,Sacchi,A.,Zupi,G.,1980. Adriamycin effect on the Lewis lung carcinoma: comparison between the original line and its derivative subline. Europ.J.Cancer, in pressGoogle Scholar
- Lotan,R. and Nicolson,G.L.,1979. Heterogeneity in growth inhibition by Ptransretinoic acid of metastatic B16 melanoma clones and in vivo-selected cell variant lines. Cancer Res., 39: 4767–4771Google Scholar
- Sacchi,A., Corsi,A., Caputo,M., Zupi,G., 1979. In vitro and in vivo selection of two Lewis lung carcinoma cell lines. Tunori, 65: 657–664Google Scholar
- Zupi,G., Mauro,F., Sacchi,A.,1980. Cloning in vitro and in vivo of Lewis lung carcinoma: properties and characteristics. Brit.J.Cancer, 41: Suppl.IVGoogle Scholar