Advertisement

Metastasis pp 23-27 | Cite as

Models of Prostate, Breast, Lung, and Intestinal Carcinomas Which Metastasize in Rats

  • M. Pollard
Part of the Developments in Oncology book series (DION, volume 4)

Abstract

The optimal model tumor system should manifest the following characteristics: the tumor should simulate the human counterpart disease. It should be organ-related, autochthonous, and malignant. The tumor cells should multiply non-synchronously, have multiple karyotypes, and metastasize spontaneously from extravascular sites. Control animals should not develop other tumors spontaneously in the course of experimental procedures. Model systems have been developed and used in this laboratory in mice with reticulum cell sarcoma (SJL/J strain), lymphatic leukemia (AKR strain), mammary adenocarcinoma (C3H strain), and lupus-like disease in Haas strain mice (Pollard & Sharon, 1970, Pollard, et al, 1976b). Model systems do not usually comply with all of the above characteristics. In the present report, model adenocarcinomas (CAs) of prostate, lung, breast, and intestine are described in germfree (GF) and in conventional rats (Table I).

Keywords

Prostate Adenocarcinoma Cancer Treatment Report Reticulum Cell Sarcoma Hind Footpad Model Adenocarcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pollard, Morris, 1972. Spontaneous and induced neoplasms in germfree rats. In: Environment and Cancer, The Williams and Wilkins Co.,Baltimore, 394–406.Google Scholar
  2. Pollard, Morris, 1973. Spontaneous prostate adenocarcinomas in aged germfree Wistar rats. J. Nat. Cancer Inst., 51: 1235–1241.PubMedGoogle Scholar
  3. Pollard, Morris, 1975a. Prostate adenocarcinomas in Wistar rats. Medical Bulletin (Rush-Presbyterian-St. Luke’s), 14 (1): 17–22.Google Scholar
  4. Pollard, Morris, 1979a. Unpublished information.Google Scholar
  5. Pollard, Morris, Burleson, G.R. and Luckert, P.H., 1977a. Factors that modify the rate and extent of spontaneous metastases of prostate tumors in rats. In: Cancer Invasion and Metastasis: Biologic Mechanisms and Therapy (Ed: S.B. Day et al ), Raven Press, N.Y., pp 357–366.Google Scholar
  6. Pollard, Morris, Chang, C.F., and Burleson, G.R., 1977b. Investigations on prostate adenocarcinomas in rats. Cancer Treatment Reports, 61 (2): 153–156.Google Scholar
  7. Pollard, Morris and Luckert, P. H., 1975b. Transplantable metastasizing pronta adenocarcinomas in rats. J. Nat. Cancer Inst., 54 (3): 643–649.PubMedGoogle Scholar
  8. Pollard, Morris and Luckert, P. H., 1976a. Chemotherapy of metastatic prostate adenocarcinomas in germfree rats. Cancer Treatment Reports, 60: 619–621.PubMedGoogle Scholar
  9. Pollard, Morris and Luckert, P. H., 1979b. Patterns of spontaneous metastasis manifested by three rat prostate adenocarcinomas. Jr. Surg.Oncology, 12: 371–372CrossRefGoogle Scholar
  10. Pollard, Morris and Luckert, P. H., 1979c. Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors. Cancer Treatment Reports, In press.Google Scholar
  11. Pollard, Morris and Luckert, P. H., 1979d. Promotional effect of sodium barbiturate on intestinal tumors induced in rats by dimethylhydrazine. Jr. Nat. Cancer Inst., 63: 1089–1092.Google Scholar
  12. Pollard, Morris and Sharon, N., 1970. Chemotherapy of spontaneous leukemia in germfree AKR mice. Jr. Nat. Cancer Inst. 45: 677–680.Google Scholar
  13. Pollard, Morris, Truitt, R. L., and Ashman, R. B., 1976b. Mouse leukemia and solid tumors treated with bone marrow grafting. Transplant. Proc. 8: 565–567.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1980

Authors and Affiliations

  • M. Pollard

There are no affiliations available

Personalised recommendations