Models of Prostate, Breast, Lung, and Intestinal Carcinomas Which Metastasize in Rats
The optimal model tumor system should manifest the following characteristics: the tumor should simulate the human counterpart disease. It should be organ-related, autochthonous, and malignant. The tumor cells should multiply non-synchronously, have multiple karyotypes, and metastasize spontaneously from extravascular sites. Control animals should not develop other tumors spontaneously in the course of experimental procedures. Model systems have been developed and used in this laboratory in mice with reticulum cell sarcoma (SJL/J strain), lymphatic leukemia (AKR strain), mammary adenocarcinoma (C3H strain), and lupus-like disease in Haas strain mice (Pollard & Sharon, 1970, Pollard, et al, 1976b). Model systems do not usually comply with all of the above characteristics. In the present report, model adenocarcinomas (CAs) of prostate, lung, breast, and intestine are described in germfree (GF) and in conventional rats (Table I).
KeywordsLeukemia Adenocarcinoma Aspirin Heparin Sarcoma
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- Pollard, Morris, 1972. Spontaneous and induced neoplasms in germfree rats. In: Environment and Cancer, The Williams and Wilkins Co.,Baltimore, 394–406.Google Scholar
- Pollard, Morris, 1975a. Prostate adenocarcinomas in Wistar rats. Medical Bulletin (Rush-Presbyterian-St. Luke’s), 14 (1): 17–22.Google Scholar
- Pollard, Morris, 1979a. Unpublished information.Google Scholar
- Pollard, Morris, Burleson, G.R. and Luckert, P.H., 1977a. Factors that modify the rate and extent of spontaneous metastases of prostate tumors in rats. In: Cancer Invasion and Metastasis: Biologic Mechanisms and Therapy (Ed: S.B. Day et al ), Raven Press, N.Y., pp 357–366.Google Scholar
- Pollard, Morris, Chang, C.F., and Burleson, G.R., 1977b. Investigations on prostate adenocarcinomas in rats. Cancer Treatment Reports, 61 (2): 153–156.Google Scholar
- Pollard, Morris and Luckert, P. H., 1979c. Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors. Cancer Treatment Reports, In press.Google Scholar
- Pollard, Morris and Luckert, P. H., 1979d. Promotional effect of sodium barbiturate on intestinal tumors induced in rats by dimethylhydrazine. Jr. Nat. Cancer Inst., 63: 1089–1092.Google Scholar
- Pollard, Morris and Sharon, N., 1970. Chemotherapy of spontaneous leukemia in germfree AKR mice. Jr. Nat. Cancer Inst. 45: 677–680.Google Scholar