Immune Regression of Metastases Following Hyperthermic Treatment of Primary Tumours
In the present renewal of interest in the use of hyperthermia (temperatures ≥ 42°C) for the treatment of cancer, a striking finding has been the disappearance of established metastases with host cure following effective heating of the primary tumour. This was first reported by Strauss for the Brown-Pearce carcinoma in the rabbit, and we have confirmed the occurrence of this phenomenon (the ‘abscopal’ response) for 3 different rat tumours and 2 strains of rabbit tumour, encompassing both allogeneic and syngeneic systems (Table 1).
KeywordsTumour Blood Flow Curative Heating HYPERTHERMIC Treatment Host Cure Hyperthermic Perfusion
Unable to display preview. Download preview PDF.
- Calderwood, S.K. and Dickson, J.A., In press. Effect of hyperglycemia on the blood flow, pH and response to hyperthermia of the Yoshida sarcoma in the rat. Cancer Res.Google Scholar
- Currie, G.A., 1974. Cancer and the Immune Response. Ed. Arnold, London.Google Scholar
- Dickson, J.A., 1978. The sensitivity of human cancer to hyperthermia. In: W.L. Caldwell and R.E. Durand (editors), Proc. Conf. Clinical Prospects for Hypoxic Cell Sensitizers and Hyperthermia. Univ. of Wisconsin Press, Madison, Wisconsin, pp. 174–193.Google Scholar
- Goldenberg, D.M. and Langner, M., 1971. Direct and abscopal antitumour action of local hyperthermia. Z. Naturforsch, 26b: 359–361.Google Scholar
- Sapirstein, L.A., 1958. Regional blood flow by fractional distribution of indicators. Amer. J. Physiol., 193: 163–168.Google Scholar
- Shah, S.A. and Dickson, J.A., 1980. Effects of immunosuppression on the response of animal tumours to hyperthermia. In preparation.Google Scholar
- Strauss, A.A., 1969. Immunologic Resistance to Carcinoma Produced by Electrocoagulation. Based on Fifty-Seven Years of Experimental and Clinical Results. Chas. C. Thomas, Springfield, Illinois.Google Scholar