Immune Regression of Metastases Following Hyperthermic Treatment of Primary Tumours
In the present renewal of interest in the use of hyperthermia (temperatures ≥ 42°C) for the treatment of cancer, a striking finding has been the disappearance of established metastases with host cure following effective heating of the primary tumour. This was first reported by Strauss for the Brown-Pearce carcinoma in the rabbit, and we have confirmed the occurrence of this phenomenon (the ‘abscopal’ response) for 3 different rat tumours and 2 strains of rabbit tumour, encompassing both allogeneic and syngeneic systems (Table 1).
KeywordsElectrophoresis Fractionation Sarcoma Polyacrylamide Hyperglycemia
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