Effect of Fibrinolysis Inhibition on the Growth and Hematogenous Dissemination of Cancer
The coagulation-fibrinolysis system is considered to be an important factor in the growth and spread of tumors (Kodama, 1974; Kinjo, 1978). At the advancing border of the tumors, deposition of fibrin has been clearly demonstrated and was shown to be more prominent in tumors with high thromboplastic activity than in those with low activity (Kodama, 1978). On the other hand, a varying degree of fibrinolytic activity was found in cancer cells and fibrinolytic activity was also observed in small blood vessels at the advancing border of tumors (Tanaka, 1977). Fibrinolysis is considered to be related to resolution of fibrin depositing around the primary tumor and also around the arrested tumor cells in the vessels of target organs of hematogenous metastasis. Inhibition of fibrinolysis may lead to more prominent deposition of fibrin around the tumor and promote the development of a stromal reaction by the host against malignant growth and may also inhibit the release of cancer cells into the vessels. The present experiments were planned to elucidate the role of the coagulation-fibrinolysis system in the growth and spread of tumors and to examine the clinical applicability of antifibrinolytic agents.
KeywordsEDTA Trypsin Cyclophosphamide Fibrinogen Aminomethyl
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