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Metastasis pp 116-121 | Cite as

Effect of Fibrinolysis Inhibition on the Growth and Hematogenous Dissemination of Cancer

  • K. Tanaka
  • M. Kinjo
  • A. Iwakawa
  • H. Ogawa
  • N. Tanaka
Part of the Developments in Oncology book series (DION, volume 4)

Abstract

The coagulation-fibrinolysis system is considered to be an important factor in the growth and spread of tumors (Kodama, 1974; Kinjo, 1978). At the advancing border of the tumors, deposition of fibrin has been clearly demonstrated and was shown to be more prominent in tumors with high thromboplastic activity than in those with low activity (Kodama, 1978). On the other hand, a varying degree of fibrinolytic activity was found in cancer cells and fibrinolytic activity was also observed in small blood vessels at the advancing border of tumors (Tanaka, 1977). Fibrinolysis is considered to be related to resolution of fibrin depositing around the primary tumor and also around the arrested tumor cells in the vessels of target organs of hematogenous metastasis. Inhibition of fibrinolysis may lead to more prominent deposition of fibrin around the tumor and promote the development of a stromal reaction by the host against malignant growth and may also inhibit the release of cancer cells into the vessels. The present experiments were planned to elucidate the role of the coagulation-fibrinolysis system in the growth and spread of tumors and to examine the clinical applicability of antifibrinolytic agents.

Keywords

Fibrinolytic Activity Lewis Lung Carcinoma Lewis Lung Carcinoma Cell Antifibrinolytic Agent Fibrinolysis Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Kinjo, M., 1978. Lodgement and extravasation of tumor cells in blood-borne metastasis: An electron microscope study. Br.J.Cancer, 38: 293–301.PubMedCrossRefGoogle Scholar
  2. Kodama, Y., 1974. Experimental studies on significance of coagulationfibrinolysis system in growth and metastasis formation of rabbit V2 and V7 carcinomas. Fukuoka Acta Med., 65: 941–966.(in Japanese)Google Scholar
  3. Peterson, H.I., 1968. Experimental studies of fibrinolysis in growth and spread of tumor. Acta Chir. Scand., Suppl., 394: 2–42.Google Scholar
  4. Tanaka, K., Kohga, S., Kinjo, M. and Kodama, Y., 1977. Tumor metastasis and thrombosis, with special reference to thromboplastic and fibrinolytic activities of tumor cells. GANN Monograph on Canrpr Res. 20: 97–119.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1980

Authors and Affiliations

  • K. Tanaka
  • M. Kinjo
  • A. Iwakawa
  • H. Ogawa
  • N. Tanaka

There are no affiliations available

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