Metastasis pp 69-74 | Cite as

Quantitative Studies on Metastasis Using Yoshida Rat Ascites Hepatomas, with Special Reference to the Biological Characteristics in Metastasizability and Drug Sensitivity

  • H. Sato
  • M. Suzuki
  • H. Satoh
Part of the Developments in Oncology book series (DION, volume 4)


A series of transplantable tumors of Yoshida ascites hepatomas have been used in various kinds of experimental studies in Japan, particularly on the mechanism of metastasis and chemotherapy in our laboratories.


Drug Sensitivity Free Cell Metastasis Formation Ascites Tumor Nitrogen Mustard 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


Origin and ascitic characteristics

  1. Isaka, H., Izumitani, M., Umehara, S., Sato, M. and Sato, H., 1967. Chromosomal features in ascites and metastatic lesions of cancer clones. Gann, 58: 167–175.PubMedGoogle Scholar
  2. Odashima, S., 1964. Establishment of ascites hepatomas in the rat, 1951–1962. Ascites Tumors, Yoshida Sarcoma and Ascites Hepatoma(s), Yoshida T. and Sato H. (Eds), Nat. Cancer Inst. Monograph No. 16, pp. 51–93.Google Scholar
  3. Yoshida, T., Sato, H. and Aruji, T., 1951. Origin of the Yoshida sarcoma I. Experimental production of “Ascites Hepatoma” in the rat. Proc. Japan Acad. 27: 485–492.Google Scholar

Transplantability and survival

  1. Sato,H., 1955. Intraperitoneal transplantation of the Yoshida sarcoma and the ascites hepatoma to various American strains of rats. J. Nat. Cancer Inst., 15 (5): 1367–1378.PubMedGoogle Scholar
  2. Sato, H., Essner, E. and Belkin, M., 1955. Experiments on an ascites hepatoma. II. Intraperitoneal transplantation of free tumor cells separated from island of the rat ascites hepatoma. Experim. Cell Res., 9 (3): 381–392.CrossRefGoogle Scholar
  3. Satoh, H., 1964. Transplantability of Yoshida Sarcoma. NCI Monograph, 16: 7–49.Google Scholar
  4. Sato, H., Satoh, H. and Kuroki, T., 1966. Quantitative analysis of malignancy. Evaluation of transplantability and survival. Gann Monograph, 1: 29–42.Google Scholar
  5. Sato, H. and Fujii, K., 1957. Quantitative analysis of the acquired resistance in tumor bearing hosts. Tohoku J. exp. Med., 91: 397–407.CrossRefGoogle Scholar

Metastasis and tumor cell appearance in the blood

  1. Hori, K., Suzuki, M., Abe, I., Saito, S. and Sato, H., 1979. A model of lymph node metastasis by transplantation of tumor cells into rat ear. Gann, 70: 383–384.PubMedGoogle Scholar
  2. Khato, J., Suzuki, M. and Sato, H., 1974. Quantitative study on thromboplastin in various strains of Yoshida ascites hepatoma cells of rat. Gann, 65: 289–294.PubMedGoogle Scholar
  3. Khato, J., Nakadate, T., Suzuki, M. and Sato, H., 1975. Quantitative studies on lung metastases, with reference to the number and size of tumor nodures produced by intravenous inoculation of tumor cells. Sci. Rep. Res. Inst. Tohoku Univ. -C, 22 (3–4): 69–76.Google Scholar
  4. Khato, J., Sato, T., Sato, H., Abe, K., Endo, E., Ohta, E. and Fukuoka, Y., 1977. Hematological alterations in tumor-bearing rats, with reference to pathogenesis of chronic type of disseminated intravascular coagulation syndrome. Gann, 68: 797–804.PubMedGoogle Scholar
  5. Kurokawa, Y., 1970. Experiments on lymph node metastasis by intralymphatic inoculation of rat ascites tumor cells, with special reference to lodgment, passage and growth of tumor cells in lymph nodes. Gann, 61: 461–471.PubMedGoogle Scholar
  6. Narisawa, T., 1966. Tumor extension from the glomeruli to the tubuli in experimental kidney metastasis. Tohoku J. exp. Med., 88: 245–256.PubMedCrossRefGoogle Scholar
  7. Sato, H., 1959. Experimental studies on the mechanism of metastasis formation. Acta Path. Jap., 9: 685.PubMedGoogle Scholar
  8. Sato, H., 1962. Cancer cells in the circulating blood with reference to cancer metastasis. Bull. Wld. Hlth. Org., 26: 675.Google Scholar
  9. Sato, H., 1964. Cancer metastasis and ascites tumors. Nat. Cancer Inst. Monograph, 16: 241–261.Google Scholar
  10. Sato, H. and Suzuki, M., 1973. Experimental studies on metastasis formation, with special reference to the mechanism of cancer cell lodgement in the microcirculation. Excepta Medica International Congress Series No. 269, ATHEROGENESIS-II, 168–176.Google Scholar
  11. Takahashi, T., 1966. Experimental studies on lung tumor by implantation of tumor cells through the air passage. Gann, 57: 337–352.PubMedGoogle Scholar
  12. Yamaura, H. and Sato, H., 1973. Experimental studies on angiogenesis in AH109P. ascites tumor tissue transplanted to a transparent chamber in rats. Chemotherapy of Cancer Dissemination and Metastasis. Edited by S. Garattini and G. Franchi, Raven Press, New York, 149–175.Google Scholar
  13. Yamaura, H. and Sato, H., 1974. Quantitative studies on the developing vascular system of rat hepatoma. J. Nat. Cancer Inst., 53: 1229–1240.PubMedGoogle Scholar

Motility and deformability

  1. Essner, E., Sato, H. and Belkin, M., 1954. Experiments on an ascites hepatoma. I. Enzymatic digestion and alkaline degradation of the cementing substance and separation of cells in tumor islands. Experim. Cell Res., 7: 430–437.CrossRefGoogle Scholar
  2. Goto, M. and Sato, H., 1965. Studies on tissue culture of ascites tumors. III. Colony formation of Yoshida sarcoma cells in agar medium. Sci. Rep. Res. Inst. Tohoku Univ. -C, 12: 319–323.Google Scholar
  3. Hosaka, S., Khato, J., Goto, M., Suzuki, M. and Sato, H., 1977. Quantitative study on the dispersiveness of cultured tumor cells, with reference to the invasiveness of cancer. Sci. Rep. of the Research Inst. Tohoku Univ. -C. 2.4(2–4): 61–67.Google Scholar
  4. Hosaka, S., Suzuki, M., Goto, M. and Sato, H., 1978. Motility of rat ascites hepatoma cells, with reference to malignant characteristics in cancer metastasis. Gann, 69: 273–276.PubMedGoogle Scholar
  5. Hosaka, S., Suzuki, M. and Sato, H., 1979. Leucocyte-like motility of cancer cells, with reference to the mechanism of extravasation in metastasis. Gann (JJCR), 70: 559–561.Google Scholar
  6. Khato, J., Sato, H., Suzuki, M. and Sato, H., 1979. Filtrability and flow charäc-teristics of leukemic and non-leukemic tumor cell suspension through polycarbonate filters in relation to hematogeneous spread of cancer. Tohoku J. exp. Med., 128: 273–284.PubMedCrossRefGoogle Scholar
  7. Kuroki, T., Goto, M. and Sato, H., 1965. Studies on in vitro growth of Yoshida sarcoma cells. I. Culture of a small number of cells with references to the role of erythrocytes. Gann, 56: 35–47.PubMedGoogle Scholar
  8. Nakadate, T., Suzuki, M. and Sato, H., 1979. Quantitative study on the liberation of tumor cells into the circulating blood. Gann(JJCR), 70: 435–446.Google Scholar
  9. Sato, H., Kuroki, T. and Goto, M., 1968. Tissue culture of rat ascites hepatomas on fluid and agar media. Cancer Cells in Culture, Edited by Katsuta. University of Tokyo Press, Tokyo, 35–47.Google Scholar
  10. Sato, H., Goto, M. and Kuroki, T., 1966. Culture of rat ascites hepatoma cells in agar medium and screening for anti-cancer substances. Gann Monograph, 2: 127–14CGoogle Scholar
  11. Sato, H. and Suzuki, M., 1976. Deformability and viability of tumor cells by transcapillary passage, with reference to organ affinity of metastasis in cancer Fundamental Aspects of Metastasis, edited by Leonald Weiss, North-Holland Publishing company, pp.311–317.Google Scholar
  12. Sato, H., Goto, M. and Hosaka, S., 1977. Growth behavior of ascites tumor cells in three-dimensional agar culture. Tohoku J. exp. Med., 122: 155–160.PubMedCrossRefGoogle Scholar
  13. Sato, H., Khato, J., Sato, T. and Suzuki, M., 1977. Deformability and filtrability of tumor cells through “Nucleopore” filter, with reference to viability and metastatic spread. GANN Monograph on Cancer Research, 20: 3–13.Google Scholar

Drug sensitivity

  1. Abe, I., Sato, S., Watanabe, M. and Sato, H., 1978. Mechanism of natural resistance of rat ascites hepatomas to 1-ß-D-arabinofuranosylcytosine. Gann, 69: 557–564.PubMedGoogle Scholar
  2. Abe, I., Sato, S., Watanabe, M. and Sato, H., 1978. Phosphorylation of 1–13-Darabinofuranosylcytosine by the cell-free extract of rat ascites hepatoma, in relation to the mechanism of natural resistance. Gann, 69: 565–568.PubMedGoogle Scholar
  3. Abe, I. and Sato, H., 1979. Dephosphorylation of nucleotides of 1-ß-D-arabinofuranosylcytosine in relation to the different drug sensitivity in tumor cells. Tohoku J. exp. Med., 127: 281–288.PubMedCrossRefGoogle Scholar
  4. Isaka, H., 1964. Natural drug resistance of the ascites hepatoma in the rat. Nat. Cancer Inst. Monograph, No. 16, pp. 131–147.Google Scholar
  5. Ishidate, M., Kobayashi, K., Sakurai, Y., Sato, H. and Yoshida, T., 1951. Experimental studies on chemotherapy of malignant growth employing Yoshida sarcoma animals. (ii) The effect of N-oxide derivatives of nitrogen mustard. Proc. Japan Acad., 27 (8): 493–500.Google Scholar
  6. Satoh, H., 1956. Studies on the ascites hepatoma. XI. Different responses by different strain of ascites hepatomas of rats to chemotherapeutic treatment. Gann, 47: 334–337.Google Scholar
  7. Sato, H., 1959. Experimental studies on the effect of nitromin ( Nitrogen mustard N-oxide) upon tumor growth with special respect to inhibition of metastasis formation. Acta U.I.C.C., XV, pp. 253.Google Scholar
  8. Sato, H., 1960. Experimental studies on the role of cancer chemotherapy for prevention of recurrence and metastasis formation in malignant tumors. Acta U.I.C.C., XVI, pp. 763.Google Scholar
  9. Sato, H., 1961. Studies on the role of cancer chemotherapy for prevention of lymph node metastasis. Cancer Chemother. Rep., 13: 33–40.Google Scholar
  10. Sato, H. and Suzuki, M., 1977. Metastasis and chemotherapy, with reference to permeability of microcirculation system. Cancer Invasion and Metastasis: Biologi Mechanisms and Therapy, edited by S.B.Day et al., Raven Press, New York, pp. 145–149.Google Scholar
  11. Terui, S., 1975. Experimental study on drug sensitivity of the rat ascites hepatoma cells in embryonated eggs, Sci. Rep. Inst. Tohoku Univ. -C, 22 (1–2): 10–17.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1980

Authors and Affiliations

  • H. Sato
  • M. Suzuki
  • H. Satoh

There are no affiliations available

Personalised recommendations